Do we Miss a Common Subset of Primary Aldosteronism in Which There is Cyclical or Exaggerated Diurnal Variation in Secretion?
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity \<0.5 nmol/h/L or renin mass \<5 ng/L), plasma sodium \> 140mmol/L or plasma potassium \< 4mmol/L.
• Patients who have been diagnosed with PA and had previous aldosterone samples \<277 pmol/L, a level which would normally not qualify for confirmatory testing.
• Patients with aldosterone results done at different times that indicate variability in production.
• Willing to consent and participate in the study.
Locations
Other Locations
United Kingdom
Queen Mary University of London
RECRUITING
London
Contact Information
Primary
Yun Ni Lee
y.n.lee@qmul.ac.uk
+442078827275
Backup
Tumi Kaminskas
research.governance@qmul.ac.uk
+442078827275
Time Frame
Start Date: 2023-02-24
Estimated Completion Date: 2027-07-24
Participants
Target number of participants: 100
Related Therapeutic Areas
Sponsors
Leads: Queen Mary University of London