A Prospective, Multi-center, Randomized Trial to Compare Statin Combined with CCB to MRA Combined with CCB in Primary Aldosteronism Treatment
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The drug treatment for primary aldosteronism (PA) is limited and difficult to improve long-term cardiovascular outcomes. This study plans to enroll patients with primary aldosteronism and randomly divide into 3 groups: scheme 1: Statin combined with amlodipine besylate, scheme 2: Statin combined with Spironolactone and Amlodipine besylate. scheme 3: Amlodipine besylate combined with Spironolactone , to observe the changes in plasma aldosterone level, 24-hour urinary aldosterone, blood pressure, and long-term cardiovascular risk.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• Clinical diagnosis of primary aldosteronism
Locations
Other Locations
China
No. 10 Changjiang River Branch, Yuzhong District,Chongqing, China
RECRUITING
Chongqing
Contact Information
Primary
sun fang
sun_fang2007@163.com
+862368729587
Time Frame
Start Date: 2024-09-10
Estimated Completion Date: 2026-09-30
Participants
Target number of participants: 180
Treatments
Experimental: Simvastatin combined with Amlodipine besylate
after 1:1 randomization, 60 patients with primary aldosteronism were treated with Simvastatin combined with Amlodipine besylate for 6 months
Experimental: Simvastatin combined with Spironolactone and Amlodipine besylate.
after 1:1 randomization, 60 patients with primary aldosteronism were treated with Simvastatin combined with Spironolactone and Amlodipine besylate for 6 months
Experimental: Amlodipine besylate combined with Spironolactone
after 1:1 randomization, 60 patients with primary aldosteronism were treated with Amlodipine besylate combined with Spironolactone for 6 months
Related Therapeutic Areas
Sponsors
Leads: Third Military Medical University