Para-chloro-2-[18F]Fluoroethyl-etomidate ([18F]CETO) as a New PET-tracer for Subtyping in Patients With Primary Aldosteronism - a Pilot Study

Status: Recruiting
Location: See location...
Intervention Type: Procedure, Drug
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY

The goal of this clinical trial is to investigate the uptake characteristics of \[18F\]CETO in adrenal tissue in patients with two different subtypes of primary aldosteronism. The main questions it aims to answer are: * What are the uptake characteristics of \[18F\]CETO in adrenal tissue in patients with primary aldosteronism? * What is the concordance between the adrenal vein sampling and the \[18F\]CETO PET/CT scan results? * What is the effect of adrenal perfusion on \[18F\]CETO uptake in the adrenal glands? Researchers will compare the results of the adrenal vein sampling to a \[18F\]CETO PET/CT scan to see if the PET/CT can accurately identify the subtypes of primary aldosteronism. Participants will: * Take dexamethasone three days prior to the scan * Undergo a \[18F\]CETO PET/CT * Report burden of pre-treatment and PET/CT scan

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• above 18 years

• Biochemically established diagnosis of PA\*

• Completion of standard diagnostic work-up of PA\*

• Able to follow and understand instructions to participate in the study

• Able to give written informed consent.

Locations
Other Locations
Netherlands
University Medical Center Groningen
RECRUITING
Groningen
Contact Information
Primary
dr. M.N. Kerstens
m.n.kerstens@umcg.nl
+31 0503613518
Backup
Merit Schaafsma, MD-PhD candidate
m.schaafsma@umcg.nl
+31503610972
Time Frame
Start Date: 2024-11-06
Estimated Completion Date: 2027-05
Participants
Target number of participants: 12
Treatments
Active_comparator: Aldosterone producing adenoma
Patients diagnosed with an aldosterone producing adenoma
Active_comparator: Bilateral adrenal hyperplasia
Patients diagnosed with bilateral adrenal hyperplasia
Related Therapeutic Areas
Sponsors
Leads: University Medical Center Groningen

This content was sourced from clinicaltrials.gov