Hyperlipoproteinemia Type 4 Overview

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Learn About Hyperlipoproteinemia Type 4

What is the definition of Hyperlipoproteinemia Type 4?
Hyperlipoproteinemia Type IV, also known as carbohydrate-inducible hyperlipemia, is a condition in which an individual has high levels of very low-density lipoprotein (LDL) cholesterol and triglycerides (types of fat) in their blood. High levels of very low-density lipoprotein cholesterol and triglycerides can cause atherosclerosis, or the build-up of plaques of fatty cholesterol in the artery walls, which can lead to heart disease or stroke. Hyperlipoproteinemia Type IV is believed to occur in individuals who have a genetic predisposition for the disease and from consuming carbohydrates and alcohol.
What are the symptoms of Hyperlipoproteinemia Type 4?
Hyperlipoproteinemia may not cause any symptoms or may cause hypertriglyceridemic waist, which is an elevated waist circumference (>90 cm in men or >85 cm in women).
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What are the current treatments for Hyperlipoproteinemia Type 4?
Treatment for hyperlipoproteinemia Type IV includes the use of metformin, a medication that lowers blood glucose (sugar); atorvastatin, a drug that lowers blood cholesterol levels; and chenodeoxycholic acid, a bile acid that lowers the production of cholesterol in the liver and its absorption in the small intestine.
Who are the top Hyperlipoproteinemia Type 4 Local Doctors?
Distinguished in Hyperlipoproteinemia Type 4
Dr. Charles D. Christian
Internal Medicine
Distinguished in Hyperlipoproteinemia Type 4
Dr. Charles D. Christian
Internal Medicine

Indiana University Health Care Associates Inc

820 N Samuel Moore Pkwy, 
Mooresville, IN 
317-217-2500
Languages Spoken:
English
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Accepting New Patients

Charles Christian is a primary care provider, practicing in Internal Medicine in Mooresville, Indiana. Dr. Christian is rated as a Distinguished provider by MediFind in the treatment of Hyperlipoproteinemia Type 4. His top areas of expertise are Heterozygous Familial Hypercholesterolemia (HeFH), Familial Hypercholesterolemia, Defective Apolipoprotein B-100, and Hyperlipoproteinemia Type 4. Dr. Christian is currently accepting new patients.

Michele D. Nacouzi
Experienced in Hyperlipoproteinemia Type 4
Dr. Michele D. Nacouzi
Family Medicine
Experienced in Hyperlipoproteinemia Type 4
Dr. Michele D. Nacouzi
Family Medicine

Duke Primary Care Brier Creek

10208 Cerny St, 
Raleigh, NC 
919-484-8345
Languages Spoken:
English, French, Spanish
See accepted insurances
Accepting New Patients
Offers Telehealth

Michele Nacouzi is a primary care provider, practicing in Family Medicine in Raleigh, North Carolina. Dr. Nacouzi is rated as an Experienced provider by MediFind in the treatment of Hyperlipoproteinemia Type 4. Her top areas of expertise are Myotonic Dystrophy, Myotonic Dystrophy Type 2, Sitosterolemia, and Paramyotonia Congenita. Dr. Nacouzi is currently accepting new patients.

 
 
 
 
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Paul Chemello
Experienced in Hyperlipoproteinemia Type 4
Dr. Paul Chemello
Family Medicine
Experienced in Hyperlipoproteinemia Type 4
Dr. Paul Chemello
Family Medicine

Advocate Medical Group Primary Care

21160 S La Grange Rd, 
Frankfort, IL 
815-469-8806
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Paul Chemello is a primary care provider, practicing in Family Medicine in Frankfort, Illinois. Dr. Chemello is rated as an Experienced provider by MediFind in the treatment of Hyperlipoproteinemia Type 4. His top areas of expertise are Sitosterolemia, High Cholesterol, Hyperlipoproteinemia Type 4, and Homozygous Familial Hypercholesterolemia (HoFH).

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What are the latest Hyperlipoproteinemia Type 4 Clinical Trials?
A Multi-center, Open Label, Multi-arm, Dose Ascending Clinical Trial for Evaluation of Safety and Tolerance of Gene Therapy Drug GC304 in the Treatment of Primary Hypertriglyceridemia Patients With History of Acute Pancreatitis
A Multi-center, Open Label, Multi-arm, Dose Ascending Clinical Trial for Evaluation of Safety and Tolerance of Gene Therapy Drug GC304 in the Treatment of Primary Hypertriglyceridemia Patients With History of Acute Pancreatitis
Enrollment Status: Recruiting
Publish Date: July 03, 2025
Intervention Type: Genetic
Study Phase: Phase 1

Summary: The study will evaluate safety and tolerance of intravenous delivery of GC304 gene therapy drug as a treatment of primary hypertriglyceridemic patients with previous onset of acute pancreatitis.

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