Hyperlipoproteinemia Type IV, also known as carbohydrate-inducible hyperlipemia, is a condition in which an individual has high levels of very low-density lipoprotein (LDL) cholesterol and triglycerides (types of fat) in their blood. High levels of very low-density lipoprotein cholesterol and triglycerides can cause atherosclerosis, or the build-up of plaques of fatty cholesterol in the artery walls, which can lead to heart disease or stroke. Hyperlipoproteinemia Type IV is believed to occur in individuals who have a genetic predisposition for the disease and from consuming carbohydrates and alcohol.

Hyperlipoproteinemia may not cause any symptoms or may cause hypertriglyceridemic waist, which is an elevated waist circumference (>90 cm in men or >85 cm in women).

Treatment for hyperlipoproteinemia Type IV includes the use of metformin, a medication that lowers blood glucose (sugar); atorvastatin, a drug that lowers blood cholesterol levels; and chenodeoxycholic acid, a bile acid that lowers the production of cholesterol in the liver and its absorption in the small intestine.