Host-microbiome Interactions in the Quest for Fibrosing ILD Biomarkers That Rule Acceleration

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

FIBRALUNG is a prospective cohort study with biobank of samples from patients with pulmonary fibrosis, aiming to explore the molecular determinants of different clinical outcomes, acute exacerbations and mortality. We expect to gain deeper insight into fibroproliferative common pathways, particularly between idiopathic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis, paving the way for new biomarkers that reflect the progressive phenotype, that eventually will support new targeted therapies. Other idiopathic interstitial pneumonias, connective tissue disease-related interstitial lung diseases and sarcoidosis patients will be also recruited and their biological samples stored for further analyses.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:

• Patients aged between 18-80 years

• People undergoing blood collection, lung biopsy and/or BAL as part of their diagnostic workup

• Willingness to undergo the follow-up protocol evaluations

• Treatment-naïve for disease-modifying drugs

• An HRCT scan performed within the last 12 months showing ≥10% fibrosis extent of the lungs

Locations
Other Locations
Portugal
Centro Hospitalar Universitário São João
RECRUITING
Porto
Contact Information
Primary
Helder Novais Bastos, MD, PhD
hnovaisbastos@med.up.pt
(+351) 220408800
Backup
Janete Santos, PhD
investigaclinica@med.up.pt
(+351) 225 513 600
Time Frame
Start Date: 2021-03-01
Estimated Completion Date: 2026-03-31
Participants
Target number of participants: 150
Treatments
IPF
Patients with Idiophatic Pulmonary Fibrosis (IPF), serving as a prototype of a progressive fibroproliferative disorder.
Progressive Pulmonary Fibrosis (non-IPF)
Patients with non-IPF interstitial lung diseases, presenting a progressive fibrosing phenotype, or acute exacerbations.
Non-Progressive Pulmonary Fibrosis (non-IPF)
Patients with fibrotic non-IPF interstitial lung diseases that are stable during a minimum follow-up of 24 months.
Sponsors
Collaborators: Instituto de Investigação e Inovação em Saúde (i3S), Fundação para a Ciência e a Tecnologia, Centro Hospitalar De São João, E.P.E.
Leads: Universidade do Porto

This content was sourced from clinicaltrials.gov