What is the definition of Hypersensitivity Vasculitis?

Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance. It leads to inflammation and damage to blood vessels, mainly in the skin. The term is not used much currently because more specific names are considered more precise.

What are the alternative names for Hypersensitivity Vasculitis?

Cutaneous small vessel vasculitis; Allergic vasculitis; Leukocytoclastic vasculitis

What are the causes for Hypersensitivity Vasculitis?

Hypersensitivity vasculitis, or cutaneous small vessel vasculitis, is caused by:

  • An allergic reaction to a drug or other foreign substance
  • A reaction to an infection

It usually affects people older than age 16.

Often, the cause of the problem cannot be found even with a careful study of medical history.

Hypersensitivity vasculitis may look like systemic, necrotizing vasculitis, which can affect blood vessels throughout the body and not just in the skin. In children, it can look like Henoch-Schonlein purpura.

What are the symptoms for Hypersensitivity Vasculitis?

Symptoms may include:

  • New rash with tender, purple or brownish-red spots over large areas
  • Skin sores mostly located on the legs, buttocks, or trunk
  • Blisters on the skin
  • Hives (urticaria), may last longer than 24 hours
  • Open sores with dead tissue (necrotic ulcers)

What are the current treatments for Hypersensitivity Vasculitis?

The goal of treatment is to reduce inflammation.

Your provider may prescribe aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), or corticosteroids to reduce inflammation of the blood vessels. (DO NOT give aspirin to children except as advised by your provider).

Your provider will tell you to stop taking medicines that could be causing this condition.

What is the outlook (prognosis) for Hypersensitivity Vasculitis?

Hypersensitivity vasculitis most often goes away over time. The condition may come back in some people.

People with ongoing vasculitis should be checked for systemic vasculitis.

What are the possible complications for Hypersensitivity Vasculitis?

Complications may include:

  • Lasting damage to the blood vessels or skin with scarring
  • Inflamed blood vessels affecting the internal organs

When should I contact a medical professional for Hypersensitivity Vasculitis?

Call your provider if you have symptoms of hypersensitivity vasculitis.

How do I prevent Hypersensitivity Vasculitis?

DO NOT take medicines that have caused an allergic reaction in the past.

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REFERENCES

Habif TP. Hypersensitivity syndromes and vasculitis. In: Habif TP, ed. Clinical Dermatology. 6th ed. Philadelphia, PA: Elsevier; 2016:chap 18.

Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum. 2013;65(1):1-11. PMID: 23045170 www.ncbi.nlm.nih.gov/pubmed/23045170.

Patterson JW. The vasculopathic reaction pattern. In: Patterson JW, ed. Weedon's Skin Pathology. 4th ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2016:chap 8.

Stone JH. The systemic vasculitides. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 270.

Sunderkötter CH, Zelger B, Chen KR, et al. Nomenclature of cutaneous vasculitis: dermatologic addendum to the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheumatol. 2018;70(2):171-184. PMID: 29136340 www.ncbi.nlm.nih.gov/pubmed/29136340.

  • Condition: Prostate cancer
  • Journal: Prostate cancer and prostatic diseases
  • Treatment Used: Androgen deprivation therapy
  • Number of Patients: 11180
  • Published —
The study researched the effects of androgen deprivation therapy (stopping the hormone androgen) for prostate cancer.

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