What is the definition of Hypersplenism?

Hypersplenism is an overactive spleen. The spleen is an organ found in the upper left side of your abdomen. The spleen helps filter old and damaged cells from your bloodstream. If your spleen is overactive, it removes the blood cells too early and too quickly.

The spleen plays a key role in helping your body fight infections. Problems with the spleen can make you more likely to develop infections.

What are the causes for Hypersplenism?

Common causes of hypersplenism include:

  • Cirrhosis (advanced liver disease)
  • Lymphoma
  • Malaria
  • Tuberculosis
  • Various connective tissue and inflammatory diseases

What are the symptoms for Hypersplenism?

Symptoms include:

  • Enlarged spleen
  • Low level of one or more types of blood cells
  • Feeling full too soon after eating
  • Stomach pain on the left side


Arber DA. Spleen. In: Goldblum JR, Lamps LW, McKenney JK, Myers JL, eds. Rosai and Ackerman's Surgical Pathology. 11th ed. Philadelphia, PA: Elsevier; 2018:chap 38.

Connell NT, Shurin SB, Schiffman F. The spleen and its disorders. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 160.

Clinical Trial
  • Status: Recruiting
  • Phase: N/A
  • Intervention Type: Device, Drug
  • Participants: 72
  • Start Date: January 5, 2021
EUS-guided Partial Splenic Embolization in Combination With EUS-guided Treatment of Varices for Patients With Portal Hypertension
Clinical Trial
  • Status: Recruiting
  • Phase: N/A
  • Intervention Type: Procedure, Drug
  • Participants: 40
  • Start Date: January 2, 2019
HVPG-guided Laparoscopic Versus Endoscopic Therapy for Variceal Rebleeding in Portal Hypertension: A Multicenter Randomized Controlled Trial (CHESS1803)