Study of Coronary Calcium Score as a Marker of Post-radiation Vascular Dysplasia in Adults Treated During Childhood for Cancer With Mediastinal Irradiation

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

To measure coronary calcium score in adults treated during childhood or adolescence for irradiation cancer in the heart and / or anthracycline area and compare them to determine whether irradiation of the heart area is associated with increased calcium score after adjustment for other cardiovascular risk factors (age, sex, smoking, dyslipidemia, obesity, diabetes, high blood pressure and renal failure).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients 18 years of age or older,

• Treated for cancer during childhood, adolescence or young adulthood (≤25 years),

• Treated with irradiation of the heart area (≥20% of ≥5Gy heart rate) and / or anthracycline (cumulative dose of doxorubicin equivalent ≥300mg/m\^²),

• In complete remission of their pediatric cancer for at least 10 years,

• Patient affiliated to a social security scheme or beneficiary of such a scheme,

• Patient Information and Signed Informed Consent.

• Patients 30 years of age or older,

• Treated for cancer during childhood, adolescence or young adulthood (≤25 years),

• Treated with irradiation of the heart area (≥20% of ≥5Gy heart rate),

• In complete remission of their pediatric cancer for at least 10 years,

• Patient affiliated to a social security scheme or beneficiary of such a scheme,

• Patient Information and Signed Informed Consent.

Locations
Other Locations
France
Hôpital Bichat
RECRUITING
Paris
Hôpital Trousseau
RECRUITING
Paris
Gustave Roussy
RECRUITING
Villejuif
Contact Information
Primary
Brice FRESNEAU, MD
brice.fresneau@gustaveroussy.fr
+33 (0)1 42 11 42 11
Time Frame
Start Date: 2018-06-14
Estimated Completion Date: 2028-09
Participants
Target number of participants: 500
Treatments
Other: Patients treated for cancer during childhood or adolescence
Patients over the age of 18 treated during childhood or adolescence for cancer with irradiation affecting the heart area (≥20% of ≥5Gy heart volume) and / or anthracyclines (≥ 300mg/m\^²)
Related Therapeutic Areas
Sponsors
Leads: Gustave Roussy, Cancer Campus, Grand Paris

This content was sourced from clinicaltrials.gov

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