Biological Sex and Sex Hormones Moderate Right Ventricular (RV) Dysfunction and Recovery in Chronic Thromboembolic Pulmonary Hypertension
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
1. To identify biological sex differences in baseline RV function in CTEPH 2. To identify biological sex differences in recovery of RV function after PTE surgery in CTEPH 3. To determine if sex hormone levels relate to RV function at CTEPH diagnosis and during recovery after PTE.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adult (≥18 years old) patients diagnosed with CTEPH per current guideline standard42
• Subject must have a baseline TTE (within 3 months of diagnosis) with adequate images for RVGLS analysis
• Subject must have a right heart catheterization (RHC) at the time of diagnosis
• To be included in the Aim 2 analysis, patients must undergo PTE surgery and have a TTE performed 3-9 months after surgery with adequate images for RVGLS strain analysis
Locations
United States
Utah
Intermountain Medical Center
RECRUITING
Murray
Time Frame
Start Date: 2022-05-30
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 10
Treatments
Retrospective Cohort Aim 1
Aims 1 and 2 are retrospective and will be conducted with the same dataset, just at two different time points (at diagnosis of CTEPH and after PTE surgery). For simplicity, aims 1 and 2 will be combined into one section throughout the protocol.
Retrospective Cohort Aim 2
Aims 1 and 2 are retrospective and will be conducted with the same dataset, just at two different time points (at diagnosis of CTEPH and after PTE surgery). For simplicity, aims 1 and 2 will be combined into one section throughout the protocol.
Prospective Cohort Aim 3
Aim 3 is prospective and will enroll a distinct set of patients from Aim 1 and 2.
Related Therapeutic Areas
Sponsors
Leads: Intermountain Health Care, Inc.