Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by hypertensive disorders of pregnancy, thus attenuating the lifelong trajectory of cardiovascular disease risk.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:
• Hypertensive disorders of pregnancy (HDP) diagnosis, specifically gestational hypertension, preeclampsia, eclampsia, or HELLP syndrome, according to ACOG guidelines
• Postpartum day 0-4
• Age ≥ 18 years
• Able to communicate in English or in Spanish
• Has an established OBGYN at an MCW or NU health system practice that has access to Epic electronic medical records.
Locations
United States
Illinois
Northwestern University
RECRUITING
Chicago
Wisconsin
Medical College of Wisconsin
RECRUITING
Milwaukee
Contact Information
Primary
Alyssa M Hernandez, DO
alyhernandez@mcw.edu
4148055285
Backup
Amandla Stanley, MSN
akstanley@mcw.edu
4148056691
Time Frame
Start Date: 2024-10-23
Estimated Completion Date: 2029-06-30
Participants
Target number of participants: 618
Treatments
Experimental: REPAIR ARM
Intensive postpartum blood pressure control with nifedipine ER initiation at systolic blood pressure (SBP) ≥140 mmHg or diastolic blood pressure (DBP) ≥90 mmHg and maintaining blood pressure \<140/90 mmHg during the first 6 weeks postpartum.
Active_comparator: CONTROL ARM
Usual care with nifedipine ER initiation at SBP ≥150 mmHg or DBP ≥100 mmHg and maintaining blood pressure \<150/100 mmHg during the first 6 weeks postpartum.
Related Therapeutic Areas
Sponsors
Leads: Medical College of Wisconsin
Collaborators: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)