Jockey Club Precision Prevention Programme on Young Onset Diabetes

Status: Recruiting
Location: See location...
Intervention Type: Drug, Device, Genetic, Behavioral, Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This is a community-based implementation program consisting of multiple components delivered by a multidisciplinary team to detect and prevent young onset diabetes with precision and value using biogenetic markers, digital tools, integrated care through public private partnership. Adults aged between 18 and 44 (inclusive) without known diabetes and with at least one risk factor for diabetes will undergo a saliva DNA and capillary blood test and complete a questionnaire. Depending on their risk levels, participants will be stratified to high risk and low risk progressors to diabetes. The high risk progressors will undergo annual oral glucose tolerance test to detect diabetes and impaired glucose tolerance (IGT). All participants will receive a personalized report indicating their genetic and modifiable risk explained by nurses or doctors. All participants will be offered regular access to webinars for education and empowerment for 2 years. The high risk group will additionally receive a 2-year risk-stratified intervention with different combinations of care interventions. These include clinical and laboratory assessment for comprehensive evaluation of cardiovascular-kidney-metabolic risks, medical and nurse consultations, empowerment by health messages, webinars, face-to-face workshops, subsidies for medications and self-monitoring tools (e.g. CGM devices, weighing scale) to motivate behavioural change. The outcomes will be analysed within the REAIM framework (reach, effectiveness, adoption, implementation and maintenance), progresssion to prediabetes or diabetes, patient reported outcomes and cost effectiveness.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 44
Healthy Volunteers: t
View:

• Aged between 18 and 44 years old

• With at least one risk factor for diabetes

Locations
Other Locations
Hong Kong Special Administrative Region
Asia Diabetes Foundation
RECRUITING
Hong Kong
Contact Information
Primary
Juliana CN Chan
jchan@cuhk.edu.hk
+85226376624
Backup
Amy Fu
afu@adf.org.hk
+85226376624
Time Frame
Start Date: 2024-11-23
Estimated Completion Date: 2028-05
Participants
Target number of participants: 9000
Treatments
Other: Low risk
Low risk progressors are those who are in the bottom 75% of the risk score based on both clinical and biogenetic risk markers
Other: High risk progressors
High risk progressors are those who are in the top 25% of the risk score based on both clinical and biogenetic risk markers. They will undergo yearly OGTT to detect undiagnosed diabetes or impaired glucose tolerance (IGT) for early intervention. They will also receive low intensity team-based care with regular empowerment using webinars and whatsapp messages for 2 years.
Other: Impaired glucose tolerance (IGT)
Subjects with IGT will receive team-based care including lifestyle modification and early use of metformin, subsidized weighing scale and CGM, supplemented by WhatsApp messages and webinars for empowerment for 2 years
Other: Diabetes
Subjects with newly diagnosed diabetes will receive team-based care with structured assessment, JADE personalized report, testing for autoimmune markers, , subsidized CGM, weighing scale and medications with regular WhatsApp messages and webinars for empowerment for 2 years
Related Therapeutic Areas
Sponsors
Collaborators: Chinese University of Hong Kong, St. James' Settlement, Asia Diabetes Foundation
Leads: Juliana CN Chan

This content was sourced from clinicaltrials.gov