Study on the Application of Liquid Chromatography-Tandem Mass Spectrometry for the Determination of Aldosterone and Renin Activity in the Diagnosis of Primary Aldosteronism by Captopril Test
Primary aldosteronism (PA) is the most common cause of secondary hypertension. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is more accurate than the traditional radioimmunoassay method in measuring aldosterone. This study aims to establish a more precise diagnostic cutoff value for the captopril stimulation test (CCT) by measuring aldosterone levels using LC-MS/MS. The investigators will combine the detection results of CCT from healthy volunteers and suspected PA patients, etc., to determine the new CCT cutoff value. The investigators expect to improve the diagnostic accuracy of PA, helping clinicians identify this curable cause of hypertension earlier and more accurately, and achieving precise treatment.
• Age 18-70 years old
• BMI: 18.5-23.9kg/m²
• Gender not restricted
• Blood pressure: 100-120/60-80mmHg
• No history of hypertension
• No abnormal nodules found in adrenal CT
• Previous blood potassium and electrocardiogram were all within normal ranges
• No history of liver or kidney dysfunction, malignant tumors, metabolic diseases or cardiovascular diseases
• No medication used
• Patients with suspected primary aldosteronism in the outpatient setting
• Willing to undergo 4-week spironolactone treatment and cooperate with follow-up