Thyroidectomy for Graves' Disease or Amiodarone-induced Thyrotoxicosis: Is it Still Necessary to Achieve a Preoperative Euthyroid State? - A Prospective Observational Multicenter European Study (GRATES)

Status: Recruiting
Location: See all (15) locations...
Study Type: Observational
SUMMARY

The goal of this observational study is to learn about the potential differences in morbidity of thyroidectomy (removal of the thyroid gland) depending on the preoperative hormonal status. The main question it aims to answer is: Do patients undergoing thyroidectomy for thyreotoxicosis (thyroid hyperfunction) due to Graves' disease or Amiodarone induced thyreotoxicosis have comparable complication rates depending on their thyroid metabolic status prior or during the procedure. The data from participants undergoing a thyroidectomy at one of the study sites will be prospectively registered in the EUROCRINE registry, including an add-on module for additional study specific routine data. The operation itself, the preoperative or postoperative treatments are not altered in any way.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adult patients (≥ 18 years of age) undergoing surgical treatment for Graves' disease or Amiodarone-induced thyrotoxicosis (AIT) with biochemically confirmed hyperthyroidism or on specific medication for the treatment of Graves' disease or AIT.

• Patients providing signed informed consent.

Locations
Other Locations
Belgium
OLV Ziekenhuis
RECRUITING
Aalst
France
Universite de Lorraine, Cru Nancy
RECRUITING
Nancy
Greece
Evgenidion Hospital Athens
RECRUITING
Athens
Spain
Universitario Virgen de las Nieves
RECRUITING
Granada
Hospital Costa del Sol
RECRUITING
Marbella
Switzerland
Clarunis St. Clara Spital
NOT_YET_RECRUITING
Basel
Universitätsspital Bern, Inselspital
RECRUITING
Bern
University Hospitals of Geneva
RECRUITING
Geneva
University Hospital of Lausanne CHUV
RECRUITING
Lausanne
Kantonsspital Basel Land
NOT_YET_RECRUITING
Liestal
Spital Männedorf
RECRUITING
Männedorf
Ospedale Regionale di Mendrisio
RECRUITING
Mendrisio
HOCH Kantonsspital St. Gallen
RECRUITING
Sankt Gallen
Spital Limmattal
RECRUITING
Schlieren
Kantonsspital Winterthur
RECRUITING
Zurich
Contact Information
Primary
Andrea Goldmann, MD
andrea.goldmann@ksw.ch
052 266 21 21
Time Frame
Start Date: 2025-07-01
Estimated Completion Date: 2027-12
Participants
Target number of participants: 486
Treatments
euthyreoid
Patients undergoing thyroidectomy in a euthyreoid state.
non-euthyreoid
Patients undegoing thyroidectomy in a non-euthyreoid state.
Sponsors
Collaborators: ASZ Aalst, Ospedale Regionale di Mendrisio, Insel Gruppe AG, University Hospital Bern, Spital Männedorf, Kantonsspital St. Gallen, Switzerland, St. Claraspital AG, Centre Hospitalier Universitaire Vaudois, University Hospital, Geneva, Spital Limmattal Schlieren, Hospital Costa del Sol, University of Nancy, Cantonal Hosptal, Baselland, University Hospital Virgen de las Nieves, Evgenidion Hospital Athens, Greece
Leads: Andrea Goldmann

This content was sourced from clinicaltrials.gov