Non-Invasive Mapping of Cerebral Autoregulation Using Near Infrared Spectroscopy

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The investigators propose to employ advanced multi-channel near non-invasive near infrared spectroscopy (NIRS) system married with entirely non-invasive continuous arterial blood pressure (niABP) monitor to create a new wearable and portable imaging system that derives CA maps of the entire brain with high sampling rates at each point. The objectives of this project are as follows: 1. To perform in vivo testing and optimization of the device using a block-trial design to evaluate the CA mapping system's performance during various perturbations. 2. To explore the impact of aging and sex on regional disparities in CA in a healthy volunteer population using static recording along with perturbation testing.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Healthy volunteers (male and female)

• Age \> 17

Locations
Other Locations
Canada
Health Sciences Centre (HSC)
RECRUITING
Winnipeg
Contact Information
Primary
Frederick A Zeiler, MD PhD FRCSC
Frederick.Zeiler@umanitoba.ca
+1 (431) 335-7461
Time Frame
Start Date: 2023-07-11
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 250
Treatments
Other: Block Testing
Perturbations to the system will be investigated through a series of testing (block design separated by baseline rest): A. transient hyperemic response testing via carotid compression methods, B. orthostatic challenge responses (lying-to-sit, sit-to-stand),8 C. vascular chemo-reactivity via fast and slow breathing exercises and D. impact of neurovascular coupling through cognitive/Stroop testing. Work here will establish areas for improvement in real time.
Related Therapeutic Areas
Sponsors
Collaborators: Health Sciences Centre, Winnipeg, Manitoba, Natural Sciences and Engineering Research Council, Canada
Leads: University of Manitoba

This content was sourced from clinicaltrials.gov