The Use of Isocapnic Hyperventilation (iHV) for Treatment of Methanol Poisoned Patients
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
The projects investigate if treatment with isocapnic hyperventilation can eliminate methanol from the body in a similar manner to dialysis. This is achieved by administering the antidote (fomepizole) and let the patient breathe on a isocapnic hyperventilation device while samples of blood, urine and maybe the breath are collected to measure the contents of methanol and its metabolites.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• Adult patients, men \& women diagnosed with methanol poisoning
• Serum-methanol ≥ 50 mg/dL (16 mM)
• pH ≥ 7.0, and correctable by bicarbonate infusion
• no (newly developed) visual disturbances
Locations
Other Locations
Islamic Republic of Iran
Loghman-Hakim Hospital,
RECRUITING
Tehran
Contact Information
Primary
Knut Erik Hovda, MD, Ph D
knuterikhovda@gmail.com
+4799618356
Backup
Hossein Hassanian-Moghaddam, MD
hasanian2000@yahoo.com
Time Frame
Start Date: 2023-12-20
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 30
Treatments
Experimental: Isocapnic hyperventilation (iHV)
Loading dose of fomepizole on clinical suspicion; A) History of intake of alcohol of unknown/illegal origin plus symptoms potentially occurring from methanol, or B) history as above and verified methanol poisonings among people drinking the same alcohol, or C) metabolic acidosis of unknown origin (where methanol cannot be excluded as the cause;or D) a combination of these.~● iHV started after a S-methanol concentration \> 50 mg/dL is obtained (typically within 4 hours) and initial acidosis is partly or fully corrected by sodium bicarbonate (BD \<15mM, HCO3- \>10mM)
Related Therapeutic Areas
Sponsors
Collaborators: Baharloo Hospital, Teheran, Iran, Shohada-e-Tajrish Hospital, Teheran, Iran, Loghman-Hakim Hospital, Teheran, Iran, Khorshid Hospital, Isfahan University of Medical Sciences, Iran, Imam Reza Hospital, Mashhad University of Medical Sciences, Iran
Leads: Oslo University Hospital