Learn About Hypervitaminosis D

What is the definition of Hypervitaminosis D?

Hypervitaminosis D is a condition that occurs after taking very high doses of vitamin D.

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What are the alternative names for Hypervitaminosis D?

Vitamin D toxicity

What are the causes of Hypervitaminosis D?

The cause is excess intake of vitamin D. The doses need to be very high, far above what most medical providers normally prescribe.

There has been a lot of confusion about vitamin D supplementation. The recommended daily allowance (RDA) for vitamin D is between 400 and 800 IU/day, according to age and pregnancy status. Higher doses may be needed for some people, such as those with vitamin D deficiency, hypoparathyroidism, and other conditions. However, most people do not need more than 2,000 IU of vitamin D a day.

For most people, vitamin D toxicity only occurs with vitamin D doses above 10,000 IU per day.

What are the symptoms of Hypervitaminosis D?

An excess of vitamin D can cause an abnormally high level of calcium in the blood (hypercalcemia). This can severely damage the kidneys, soft tissues, and bones over time.

The symptoms include:

  • Constipation
  • Decreased appetite (anorexia)
  • Dehydration
  • Fatigue and confusion
  • Frequent urination
  • Irritability
  • Muscle weakness
  • Vomiting
  • Excessive thirst (polydipsia)
  • High blood pressure
  • Passing large amounts of urine (polyuria)
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What are the current treatments for Hypervitaminosis D?

Your provider will likely tell you to stop taking vitamin D. In severe cases, other treatment may be needed.

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What is the outlook (prognosis) for Hypervitaminosis D?

Recovery is expected, but permanent kidney damage can occur.

What are the possible complications of Hypervitaminosis D?

Health problems that can result from taking too much vitamin D over a long time include:

  • Dehydration
  • Hypercalcemia
  • Kidney damage
  • Kidney stones
When should I contact a medical professional for Hypervitaminosis D?

Call your provider if:

  • You or your child shows symptoms of hypervitaminosis D and has been taking more vitamin D than the RDA
  • You or your child shows symptoms and has been taking a prescription or over-the-counter form of vitamin D
How do I prevent Hypervitaminosis D?

To prevent this condition, pay careful attention to the correct vitamin D dose. Use vitamin D supplements from reliable licensed sources.

Many combination vitamin supplements contain vitamin D, so check the labels of all the supplements you are taking for vitamin D content.

What are the latest Hypervitaminosis D Clinical Trials?
Prospective Interventional Study of Bone Mineral Density and Vascular Calcifications in the Population of Lithiasis Patients With Idiopathic Hypercalciuria
Summary: In industrialized countries, it is estimated that around 10% of the population suffers from nephrolithiasis (NL). Numerous recent epidemiological studies report that the prevalence and incidence of NL continue to increase, with a prevalence that has nearly doubled over the past two decades. A patient who presented with a first episode of renal lithiasis has an estimated recurrence rate of nearly 5...
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What are the Latest Advances for Hypervitaminosis D?
Granulocyte to Lymphocyte Ratio among Different Categories of Neonatal Sepsis according to their Vitamin D Status.
Summary: Granulocyte to Lymphocyte Ratio among Different Categories of Neonatal Sepsis according to their Vitamin D Status.
A randomised trial of vitamin D in acute-stage allergic bronchopulmonary aspergillosis complicating asthma.
Summary: A randomised trial of vitamin D in acute-stage allergic bronchopulmonary aspergillosis complicating asthma.
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Open-label study of treatment with alendronate sodium plus vitamin D in men and women with osteoporosis in Thailand.
Summary: Open-label study of treatment with alendronate sodium plus vitamin D in men and women with osteoporosis in Thailand.
Who are the sources who wrote this article ?

Published Date: October 18, 2021
Published By: Robert Hurd, MD, Professor of Endocrinology and Health Care Ethics, Xavier University, Cincinnati, OH. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Aronson JK. Vitamin D analogues. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:478-487.

Greenbaum LA. Vitamin D deficiency (rickets) and excess. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 64.

Taylor PN, Davies JS. A review of the growing risk of vitamin D toxicity from inappropriate practice. Br J Clin Pharmacol. 2018;84(6):1121-1127. PMID: 29498758 pubmed.ncbi.nlm.nih.gov/29498758/.