Hypervitaminosis D

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Hypervitaminosis D?

Hypervitaminosis D is a condition that occurs after taking very high doses of vitamin D.

What are the alternative names for Hypervitaminosis D?

Vitamin D toxicity

What are the causes for Hypervitaminosis D?

The cause is excess intake of vitamin D. The doses need to be very high, far above what most medical providers normally prescribe.

There has been a lot of confusion about vitamin D supplementation. The recommended daily allowance (RDA) for vitamin D is between 400 and 800 IU/day, according to age and pregnancy status. Higher doses may be needed for some people, such as those with vitamin D deficiency, hypoparathyroidism, and other conditions. However, most people do not need more than 2,000 IU of vitamin D a day.

For most people, vitamin D toxicity only occurs with vitamin D doses above 10,000 IU per day.

What are the symptoms for Hypervitaminosis D?

An excess of vitamin D can cause an abnormally high level of calcium in the blood (hypercalcemia). This can severely damage the kidneys, soft tissues, and bones over time.

The symptoms include: 

  • Constipation
  • Decreased appetite (anorexia)
  • Dehydration
  • Fatigue
  • Frequent urination
  • Irritability
  • Muscle weakness
  • Vomiting
  • Excessive thirst (polydipsia)
  • High blood pressure
  • Passing large amounts of urine (polyuria)

What are the current treatments for Hypervitaminosis D?

Your provider will likely tell you to stop taking vitamin D. In severe cases, other treatment may be needed.

What is the outlook (prognosis) for Hypervitaminosis D?

Recovery is expected, but permanent kidney damage can occur.

What are the possible complications for Hypervitaminosis D?

Health problems that can result from taking too much vitamin D over a long time include:

  • Dehydration
  • Hypercalcemia
  • Kidney damage
  • Kidney stones

When should I contact a medical professional for Hypervitaminosis D?

Call your provider if:

  • You or your child shows symptoms of hypervitaminosis D and has been taking more vitamin D than the RDA
  • You or your child shows symptoms and has been taking a prescription or over-the-counter form of vitamin D

How do I prevent Hypervitaminosis D?

To prevent this condition, pay careful attention to the correct vitamin D dose.

Many combination vitamin supplements contain vitamin D, so check the labels of all the supplements you are taking for vitamin D content.


Aronson JK. Vitamin D analogues. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:478-487.

Greenbaum LA. Vitamin D deficiency (rickets) and excess. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 64.

Latest Research

Latest Advance
  • Condition: Acute Stage Allergic Bronchopulmonary Aspergillosis alongside Asthma
  • Journal: Mycoses
  • Treatment Used: Vitamin D
  • Number of Patients: 30
  • Published —
This study tested the safety and efficacy of using supplemental vitamin D alongside the standard treatment, prednisolone, to treat ABPA.
Latest Advance
  • Condition: Osteoporosis
  • Journal: BMC musculoskeletal disorders
  • Treatment Used: Alendronate sodium plus vitamin D
  • Number of Patients: 198
  • Published —
This study evaluated alendronate sodium plus vitamin D in patients with osteoporosis.

Clinical Trials

There are no recent clinical trials available for this condition. Please check back because new trials are being conducted frequently.