Learn About Hypohidrotic Ectodermal Dysplasia

What is the definition of Hypohidrotic Ectodermal Dysplasia?

Hypohidrotic ectodermal dysplasia is one of more than 100 types of ectodermal dysplasia. Starting before birth, these disorders result in the abnormal development of ectodermal tissues, particularly the skin, hair, nails, teeth, and sweat glands.

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What are the causes of Hypohidrotic Ectodermal Dysplasia?

Hypohidrotic ectodermal dysplasia is a genetic condition that can result from mutations in one of several genes. These include EDA, EDAR, EDARADD, and WNT10A. EDA gene mutations are the most common cause of the disorder, accounting for more than half of all cases. EDAR, EDARADD, and WNT10A gene mutations each account for a smaller percentage of cases. In about 10 percent of people with hypohidrotic ectodermal dysplasia, the genetic cause is unknown.

How prevalent is Hypohidrotic Ectodermal Dysplasia?

Hypohidrotic ectodermal dysplasia is the most common form of ectodermal dysplasia. It is estimated to occur in 1 in 20,000 newborns worldwide.

Is Hypohidrotic Ectodermal Dysplasia an inherited disorder?

Hypohidrotic ectodermal dysplasia has several different inheritance patterns. Most cases are inherited in an X-linked pattern and are caused by mutations in the EDA gene. A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. In females, who have two copies of the X chromosome, one altered copy of the gene in each cell often leads to less severe features of the condition. Signs and symptoms can include a few missing or abnormal teeth, sparse hair, and mild problems with sweat gland function. However, some females with one copy of the mutated gene have more severe features of this disorder.

Who are the top Hypohidrotic Ectodermal Dysplasia Local Doctors?
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University Hospital Erlangen

Erlangen University Hospital 
Erlangen, BY, DE 

Holm Schneider is in Erlangen, Germany. Schneider is rated as an Elite expert by MediFind in the treatment of Hypohidrotic Ectodermal Dysplasia. They are also highly rated in 7 other conditions, according to our data. Their top areas of expertise are Hypohidrotic Ectodermal Dysplasia, Ectodermal Dysplasias, Clouston Syndrome, and Aplasia Cutis Congenita.

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Highly rated in
8
conditions

School Of Dentistry

Rome, IT 

Michele Callea is in Rome, Italy. Callea is rated as an Elite expert by MediFind in the treatment of Hypohidrotic Ectodermal Dysplasia. They are also highly rated in 8 other conditions, according to our data. Their top areas of expertise are Hypohidrotic Ectodermal Dysplasia, Clouston Syndrome, Ectodermal Dysplasias, and Aplasia Cutis Congenita.

 
 
 
 
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Highly rated in
5
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University Hospital Erlangen

Department Of Pediatrics 
Erlangen, BY, DE 

Sigrun Wohlfart is in Erlangen, Germany. Wohlfart is rated as an Elite expert by MediFind in the treatment of Hypohidrotic Ectodermal Dysplasia. She is also highly rated in 5 other conditions, according to our data. Her top areas of expertise are Hypohidrotic Ectodermal Dysplasia, Clouston Syndrome, Ectodermal Dysplasias, and Aplasia Cutis Congenita.

What are the latest Hypohidrotic Ectodermal Dysplasia Clinical Trials?
A Prospective, Open-label, Genotype-match Controlled, Multicenter Clinical Trial to Investigate the Efficacy and Safety of Intra-amniotic ER004 as a Prenatal Treatment for Male Subjects With XLHED
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Extension Study of XLHED-Affected Male Subjects Treated With EDI200 in Protocol ECP-002
Who are the sources who wrote this article ?

Published Date:updated Last, November

Published By: National Institutes of Health

What are the Latest Advances for Hypohidrotic Ectodermal Dysplasia?
Prenatal Genetic Testing for X-Linked Hypohidrotic Ectodermal Dysplasia.
Increased risk of chronic fatigue and hair loss following COVID-19 in individuals with hypohidrotic ectodermal dysplasia.
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Genetic testing and genotype-phenotype analysis for a child with X-linked hypohidrotic ectodermal dysplasia.