HypophosphatemiaSymptoms, Doctors, Treatments, Advances & More
Learn About Hypophosphatemia
Hypophosphatemia is a low level of phosphorus (phosphate) in the blood.
Low blood phosphate; Phosphate - low; Hyperparathyroidism - low phosphate
The following may cause hypophosphatemia:
- Alcoholism
- Antacids
- Certain medicines, including insulin, acetazolamide, foscarnet, imatinib, intravenous iron, niacin, pentamidine, sorafenib, and tenofovir
- Fanconi syndrome
- Fat malabsorption in the gastrointestinal tract
- Hyperparathyroidism (overactive parathyroid gland)
- Starvation
- Too little vitamin D
Symptoms may include:
- Bone pain
- Confusion
- Muscle weakness
- Seizures
The treatment depends on the cause. Phosphate can be given by mouth or through a vein (IV).
Duke Endocrinology Clinic - Clinic 1A
Thomas Weber is an Endocrinologist practicing medicine in Durham, North Carolina. He has been practicing medicine for over 37 years. Dr. Weber is rated as an Elite provider by MediFind in the treatment of Hypophosphatemia. He is also highly rated in 24 other conditions, according to our data. His clinical expertise encompasses Hypophosphatemia, Rickets, X-Linked Hypophosphatemia, Malnutrition, and Parathyroidectomy. Dr. Weber is board certified in American Board Of Internal Med, Endocrinology, Diabetes & Meta.
Indiana University Health University Hospital
Michael Econs is an Endocrinologist practicing medicine in Indianapolis, Indiana. Dr. Econs is rated as an Elite provider by MediFind in the treatment of Hypophosphatemia. He is also highly rated in 21 other conditions, according to our data. His clinical expertise encompasses Osteosclerosis Autosomal Dominant, Osteopetrosis, X-Linked Hypophosphatemia, and Hypophosphatemia.
Yale University School Of Medicine
Karl Insogna is an Endocrinologist practicing medicine in New Haven, Connecticut. Dr. Insogna is rated as an Elite provider by MediFind in the treatment of Hypophosphatemia. He is also highly rated in 12 other conditions, according to our data. His clinical expertise encompasses Hypophosphatemia, X-Linked Hypophosphatemia, Rickets, Parathyroidectomy, and Hormone Replacement Therapy (HRT).
How well you do depends on what has caused the condition.
Contact your provider if you have muscle weakness or confusion.
Summary: The primary goal is to determine if Dipyridamole can improve serum phosphate levels and reduce the need for phosphate supplementation.
Summary: Determine the association between duration and dose of chronic conventional therapy with Pi and renal (nephrocalcinosis/nephrolithiasis), vascular (endothelial function), and cardiovascular function (echo- cardiography) in patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH) and patients with X-linked hypophosphatemia (XLH).
Published Date: October 23, 2025
Published By: Walead Latif, MD, Nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Chonchol M, Smogorzewski MJ, Stubbs, JR, Yu ASL. Disorders of calcium, magnesium, and phosphate balance. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 18.
Klemm KM, Klein MJ, Zhang Y. Biochemical markers of bone metabolism. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 16.
Yu ASL. Diseases of magnesium and phosphorus. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 105.