HypophosphatemiaSymptoms, Doctors, Treatments, Advances & More
Learn About Hypophosphatemia
Hypophosphatemia is a low level of phosphorus (phosphate) in the blood.
Low blood phosphate; Phosphate - low; Hyperparathyroidism - low phosphate
The following may cause hypophosphatemia:
- Alcoholism
- Antacids
- Certain medicines, including insulin, acetazolamide, foscarnet, imatinib, intravenous iron, niacin, pentamidine, sorafenib, and tenofovir
- Fanconi syndrome
- Fat malabsorption in the gastrointestinal tract
- Hyperparathyroidism (overactive parathyroid gland)
- Starvation
- Too little vitamin D
Symptoms may include:
- Bone pain
- Confusion
- Muscle weakness
- Seizures
The treatment depends on the cause. Phosphate can be given by mouth or through a vein (IV).
Duke Endocrinology Clinic - Clinic 1A
Thomas Weber is an Endocrinologist in Durham, North Carolina. Dr. Weber has been practicing medicine for over 37 years and is rated as an Elite provider by MediFind in the treatment of Hypophosphatemia. His top areas of expertise are Hypophosphatemia, Rickets, X-Linked Hypophosphatemia, Malnutrition, and Parathyroidectomy.
Indiana University Health University Hospital
Michael Econs is an Endocrinologist in Indianapolis, Indiana. Dr. Econs is rated as an Elite provider by MediFind in the treatment of Hypophosphatemia. His top areas of expertise are Osteosclerosis Autosomal Dominant, Osteopetrosis, X-Linked Hypophosphatemia, and Hypophosphatemia.
Yale University School Of Medicine
Karl Insogna is an Endocrinologist in New Haven, Connecticut. Dr. Insogna is rated as an Elite provider by MediFind in the treatment of Hypophosphatemia. His top areas of expertise are X-Linked Hypophosphatemia, Hypophosphatemia, Rickets, Parathyroidectomy, and Hormone Replacement Therapy (HRT).
How well you do depends on what has caused the condition.
Contact your provider if you have muscle weakness or confusion.
Summary: FGF23 is the cornerstone of phosphate / calcium / vitamin D metabolism: it is synthesized mainly by osteocytes and acts as a phosphaturizing agent, inhibitor of dihydroxyvitamin D, and inhibitor of synthesis and secretion of PTH in most tissues. The specific role of FGF23 on bone has yet to be demonstrated. In osteoblasts, overexpression of FGF23 in vitro suppresses not only osteoblastic different...
Summary: The purpose of this clinical trial is to evaluate the efficacy and safety of Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules for the treatment of participants with mild, moderate, and severe hypophosphatemia. The main questions it aims to answer are: Does enteral supplementation of Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules elevate participants' serum...
Published Date: October 23, 2025
Published By: Walead Latif, MD, Nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Chonchol M, Smogorzewski MJ, Stubbs, JR, Yu ASL. Disorders of calcium, magnesium, and phosphate balance. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 18.
Klemm KM, Klein MJ, Zhang Y. Biochemical markers of bone metabolism. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 16.
Yu ASL. Diseases of magnesium and phosphorus. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 105.