Resting Energy Expenditure and Substrate Consumption in Cardiac Arrest Patients Under Target Temperature Management

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

This study is a single-center, prospective, observational study. According to the sample size formula, an estimated 40 cases should be collected, all of whom are from the emergency intensive care unit. After successful cardiopulmonary resuscitation, the enrolled patients will be transferred to the emergency intensive care unit for further standardized target temperature management (TTM). They will be divided into 33 ° C hypothermia group and 36 ° C hypothermia group according to the patient's core body temperature. The baseline data of the patients will be collected at the beginning. After admission to the hospital, they were fasted within 24 hours to reach the target temperature, and then 20kcal/kg/d parenteral nutrition will be given. At selected time points (T0: the initial time point before TTM; T1: the core temperature was reduced to 33 ° C or 36 ° C; T2-T4: 33 ° C or 36 ° C was maintained for 24h, 48h, 72h; T5: the end of rewarming; Tend: the last REE measurement before discharge or death) , various observation indicators will be collected, including resting energy expenditure (REE), glucose oxidation rate, fat oxidation rate, protein oxidation rate, and metabolism of three major nutrients Proportion. Neurological outcomes were followed up 28 days after onset according to the Cerebral Performance Categories (CPC) score.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Be admitted to the emergency department of Beijing Chao-yang Hospital, Capital Medical University;

• Successfully resuscitated, and are unconscious after restoration of spontaneous circulation (ROSC);

• Be admitted to the intensive care unit (ICU) for advanced life support such as endotracheal intubation after restoration of spontaneous circulation (ROSC);

• Accepted target temperature management (TTM) therapy after restoration of spontaneous circulation (ROSC);

Locations
Other Locations
China
Beijing chao-yang Hospital, Capital Medical University
RECRUITING
Beijing
Contact Information
Primary
Ziren Tang, MD
tangziren1970@163.com
010-85231530
Time Frame
Start Date: 2024-06-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 40
Treatments
33℃ group
36℃ group
Related Therapeutic Areas
Sponsors
Leads: Tang Ziren

This content was sourced from clinicaltrials.gov