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PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE): a Pilot Feasibility Study

Status: Recruiting

Location: See location...

Intervention Type: Device

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface cooling device (CarbonCool® vest) in adult out-of-hospital cardiac arrest (OHCA) patients with return of spontaneous circulation (ROSC). The study aims to assess feasibility, fidelity, acceptability, and safety of initiating cooling in the field by emergency medical services (EMS) prior to hospital arrival. Results will inform the design of a larger definitive trial to determine the clinical effectiveness of early pre-hospital TTM in improving neurological outcomes.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 16

Maximum Age: 80

Healthy Volunteers: f

View:

• Out-of-hospital cardiac arrest (OHCA) of any rhythm attended by Singapore Civil Defence Force (SCDF) paramedics.

• Return of spontaneous circulation (ROSC) achieved in the pre-hospital setting.

• Age ≥16 years and ≤80 years.

• Patient remains comatose after ROSC, with Glasgow Coma Scale (GCS) ≤8.

Locations

Other Locations

Singapore

National University Heart Centre, Singapore (NUHCS)

RECRUITING

Singapore

Contact Information

Primary

Shir Lynn Lim, MBBS

shir.lynn.lim@nus.edu.sg

+65 91760383

Time Frame

Start Date: 2026-02-01

Estimated Completion Date: 2027-03

Participants

Target number of participants: 50

Treatments

Experimental: Pre-hospital Targeted Temperature Management

Eligible out-of-hospital cardiac arrest (OHCA) patients who achieve return of spontaneous circulation (ROSC) and meet inclusion criteria will receive early targeted temperature management (TTM) initiated in the pre-hospital setting by Singapore Civil Defence Force (SCDF) paramedics. Cooling is delivered using the CarbonCool® surface cooling vest, applied immediately after ROSC and maintained during transport to the receiving hospital. Upon hospital arrival, a 1-for-1 vest exchange is performed in the Emergency Department before continuation of standard post-cardiac arrest care.

Related Therapeutic Areas

Cardiac Arrest

Hypothermia

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