Immune Thrombocytopenic Purpura (ITP)Symptoms, Doctors, Treatments, Advances & More
Learn About Immune Thrombocytopenic Purpura (ITP)
Immune thrombocytopenia is a disorder characterized by a blood abnormality called thrombocytopenia, which is a shortage of blood cells called platelets that are needed for normal blood clotting.
The genetic cause of immune thrombocytopenia is unclear. This condition occurs when the body's own immune system malfunctions and attacks the body's tissues and organs (autoimmunity). Normally, the immune system produces proteins called antibodies, which attach to specific foreign particles and germs, marking them for destruction. In immune thrombocytopenia, the immune system abnormally destroys platelets and makes fewer platelets than normal. People with immune thrombocytopenia produce antibodies that attack normal platelets. The platelets are destroyed and eliminated from the body, resulting in a shortage of these cells in affected individuals. Some of these antibodies also affect the cells in the bone marrow that produce platelets (known as megakaryocytes), which leads to a decrease in platelet production, further reducing the number of platelets in the blood.
The incidence of immune thrombocytopenia is approximately 4 per 100,000 children and 3 per 100,000 adults. In adults with immune thrombocytopenia, women are affected more often than men.
Immune thrombocytopenia and other autoimmune disorders can run in families, but the inheritance pattern is usually unknown. People with a first-degree relative (such as a parent or sibling) with immune thrombocytopenia likely have an increased risk of developing the disorder themselves.
CUIMC/Herbert Irving Pavilion
Eun-ju Lee is a Hematologist and an Oncologist practicing medicine in New York, New York. Dr. Lee is rated as an Elite provider by MediFind in the treatment of Immune Thrombocytopenic Purpura (ITP). She is also highly rated in 11 other conditions, according to our data. Her clinical expertise encompasses Immune Thrombocytopenic Purpura (ITP), Thrombocytopenia, Adult Immune Thrombocytopenia, Hemangioma Thrombocytopenia Syndrome, and Splenectomy. Dr. Lee is board certified in Hematology and Internal Medicine. Dr. Lee is currently accepting new patients.
CUIMC/Herbert Irving Pavilion
Cindy Neunert is a Pediatrics provider practicing medicine in New York, New York. Dr. Neunert is rated as an Elite provider by MediFind in the treatment of Immune Thrombocytopenic Purpura (ITP). She is also highly rated in 3 other conditions, according to our data. Her clinical expertise encompasses Immune Thrombocytopenic Purpura (ITP), Multisystem Inflammatory Syndrome in Children (MIS-C), Anemia, Venous Thromboembolism (VTE), and Splenectomy. Dr. Neunert is board certified in Pediatrics and Pediatric Hematology-Oncology. Dr. Neunert is currently accepting new patients.
James Bussel is a Pediatric Hematologist Oncology provider practicing medicine in New York, New York. Dr. Bussel is rated as an Elite provider by MediFind in the treatment of Immune Thrombocytopenic Purpura (ITP). He is also highly rated in 6 other conditions, according to our data. His clinical expertise encompasses Immune Thrombocytopenic Purpura (ITP), Blood Clots, Anemia, Evans Syndrome, and Splenectomy.
Summary: The purpose of this study is to investigate the tolerability of ianalumab (9 mg/kg) with investigator's choice thrombopoietin receptor agonist (IC TPO-RA) in participants diagnosed with primary immune thrombocytopenia (ITP) who have been treated with at least one but no more than four prior treatments, and with no change in IC TPO-RA dose in at least the last 14 days prior to the start of ianaluma...
Summary: An early-phase clinical trial evaluating the safety, tolerability, and pharmacokinetics of subcutaneously dosed OM336 in adult participants with autoimmune cytopenias.
Published Date: June 01, 2017
Published By: National Institutes of Health