Blocking Interferon-γ by Ruxolitinib for Treating Inclusion Body Myositis: a Phase IIb Trial
Status: Recruiting
Location: See all (16) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
Refer to the Detailed Description section.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 45
Healthy Volunteers: f
View:
• Age ≥ 45 years
• Effective contraception for the duration of the clinical trial for fertile women of childbearing age
• Defined diagnosis of IBM according to data-derived criteria (Llyod et al, 2014): Patient must fulfill the three following criteria for being diagnosed as IBM: (1) finger flexor or quadriceps weakness; and (2) muscle biopsy showing endomysial inflammation; and (3) muscle biopsy showing invasion of nonnecrotic muscle fibers or rimmed vacuoles
• To be able to walk 6 min without assistance from another person (external assist devices permitted \[e.g., canes, walkers, or rollators\])
• Patient informed and having signed the consent for participation, possibly assisted by a trusted person
Locations
Other Locations
France
Hôpital Pellegrin - Tripode, CHU de Bordeaux
ACTIVE_NOT_RECRUITING
Bordeaux
Hôpital Pierre Wertheimer, CHU de Lyon
ACTIVE_NOT_RECRUITING
Bron
CHU Caen Normandie
ACTIVE_NOT_RECRUITING
Caen
Hôpital Henri-Mondor, APHP
RECRUITING
Créteil
Hôpital Raymond Poincaré, APHP
ACTIVE_NOT_RECRUITING
Garches
Hôpital Roger Salengro, CHU de Lille
NOT_YET_RECRUITING
Lille
Hôpital Dupuytren, CHU de Limoges
ACTIVE_NOT_RECRUITING
Limoges
Hôpital de la Timone, APHM
NOT_YET_RECRUITING
Marseille
CHU Nancy
ACTIVE_NOT_RECRUITING
Nancy
Hôtel-Dieu, CHU Nantes
NOT_YET_RECRUITING
Nantes
Hôpital Pasteur, CHU de Nice
RECRUITING
Nice
Hôpital Pitié-Salpêtrière, APHP
ACTIVE_NOT_RECRUITING
Paris
Hôpital Christian Cabrol, CHU Reims
ACTIVE_NOT_RECRUITING
Reims
Hôpital Bellevue, CHU Saint-Etienne
ACTIVE_NOT_RECRUITING
Saint-etienne
Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg