Learn About Incontinentia Pigmenti

What is the definition of Incontinentia Pigmenti?

Incontinentia pigmenti is a condition that can affect many body systems, particularly the skin. This condition occurs much more often in females than in males.

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What are the causes of Incontinentia Pigmenti?

Mutations in the IKBKG gene cause incontinentia pigmenti. The IKBKG gene provides instructions for making a protein that helps regulate nuclear factor-kappa-B. Nuclear factor-kappa-B is a group of related proteins that helps protect cells from self-destructing (undergoing apoptosis) in response to certain signals.

How prevalent is Incontinentia Pigmenti?

Incontinentia pigmenti is an uncommon disorder. Between 900 and 1,200 affected individuals have been reported in the scientific literature. Most of these individuals are female, but several dozen males with incontinentia pigmenti have also been identified.

Is Incontinentia Pigmenti an inherited disorder?

This condition is inherited in an X-linked dominant pattern. The gene associated with this condition is located on the X chromosome, which is one of the two sex chromosomes. In females (who have two X chromosomes), a mutation in one of the two copies of the gene in each cell is sufficient to cause the disorder. Some cells produce a normal amount of IKBKG protein and other cells produce none. The resulting imbalance in cells producing this protein leads to the signs and symptoms of incontinentia pigmenti.

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What are the latest Incontinentia Pigmenti Clinical Trials?
Evaluation of AMG 714 for Vitiligo: A Phase 2a Randomized Double Blind Placebo Controlled Trial (ITN086AI)

Summary: This study is designed to evaluate the efficacy of AMG 714 for the treatment of adult participants with vitiligo.

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Analysis of Specimens From Individuals With Pulmonary Fibrosis

Summary: The etiology of pulmonary fibrosis is unknown. Analyses of blood, genomic DNA, and specimens procured by bronchoscopy, lung biopsy, lung transplantation, clinically-indicated extra-pulmonary biopsies, or post-mortem examination from individuals with this disorder may contribute to our understanding of the pathogenic mechanisms of pulmonary fibrosis. The purpose of this protocol is to procure and a...

Who are the sources who wrote this article ?

Published Date: June 01, 2008Published By: National Institutes of Health

What are the Latest Advances for Incontinentia Pigmenti?
Tranexamic Acid Microinjection Alone Versus Its Combination With Fractional Carbon Dioxide Laser in Melasma Treatment: A Dermoscopic Evaluation.
Treatment of vitiligo with 308-nm light emitting diode: Our experience from a two-year follow-up of Chinese patients.
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Incontinentia pigmenti in a newborn boy.