Neutropenia is an abnormally low number of white blood cells. These cells are called neutrophils. They help the body fight infection. This article discusses neutropenia in newborns.
White blood cells (WBCs) are produced in the bone marrow. They are released into the bloodstream and travel wherever they are needed. Low levels of neutrophils occur when the bone marrow cannot replace them as fast as needed.
In babies, the most common cause is infection. A very severe infection may cause neutrophils to be used up quickly. It may also prevent the bone marrow from producing more neutrophils.
Sometimes, an infant who is not sick will have a low neutrophil count for no obvious reason. Some disorders in the pregnant mother, such as preeclampsia, can also lead to neutropenia in infants.
In rare cases, mothers may have antibodies against their baby's neutrophils. These antibodies cross the placenta before birth and cause the baby's cells to break down (alloimmune neutropenia). In other rare cases, a problem with the baby's bone marrow may lead to decreased WBC production.
The source of any infection should be found and treated.
In many cases, neutropenia goes away on its own as the bone marrow recovers and begins to produce enough WBCs.
In rare cases when the neutrophil count is low enough to be life threatening, the following treatments may be recommended:
Jordan Orange is a Pediatric Allergy and Immunologist and a Pediatrics expert in New York, New York. Orange is rated as an Elite expert by MediFind in the treatment of Infantile Neutropenia. He is also highly rated in 15 other conditions, according to our data. His top areas of expertise are Infantile Neutropenia, Common Variable Immune Deficiency, Severe Combined Immunodeficiency (SCID), and Wiskott-Aldrich Syndrome. He is licensed to treat patients in Pennsylvania.
David Dale is a Hematologist Oncology expert in Seattle, Washington. Dale has been practicing medicine for over 57 years and is rated as an Elite expert by MediFind in the treatment of Infantile Neutropenia. He is also highly rated in 12 other conditions, according to our data. His top areas of expertise are Chronic Familial Neutropenia, Agranulocytosis, Infantile Neutropenia, Cyclic Neutropenia, and Bone Marrow Transplant. He is licensed to treat patients in Washington. Dale is currently accepting new patients.
Elio Castagnola practices in Genoa, Italy. Castagnola is rated as an Elite expert by MediFind in the treatment of Infantile Neutropenia. He is also highly rated in 18 other conditions, according to our data. His top areas of expertise are Infantile Neutropenia, Agranulocytosis, Febrile Neutropenia, Bone Marrow Transplant, and Appendectomy.
The baby's outlook depends on the cause of the neutropenia. Some infections and other conditions in newborns can be life threatening. However, most infections do not cause long-term side effects after the neutropenia goes away or is treated.
Alloimmune neutropenia will also get better once the mother's antibodies are out of the baby's bloodstream.
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Published Date: December 10, 2021
Published By: Neil K. Kaneshiro, MD, MHA, Clinical Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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