Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation? A Randomized Control Trial.
Premature ovarian failure (POI) is a loss of normal function before age 40, leading to infertility and hypoestrogenism. About 1% of women younger than 40 years old and 0.1% before 30 are affected. Most patients already had impaired or complete loss of fecundity when diagnosed. Hence, the treatment of POI is particularly tough. Currently, no optimal regimen exists to ameliorate ovarian function.
• Signed and dated informed consent
• Women 40 years of age and younger with documented primary ovarian insufficiency (12).
• Normal Karyotype
• BMI \</= 35 kg/m2
• Oligo/amenorrhea for at least 4 months
• FSH \> 25 IU/mL
• AMH \</= 0,1 ng/ml
• No evidence of follicles \> 4mm
• Must have two ovaries of approximately equal volume.
• Willingness to undergo further fertility treatment, including IVF if there is evidence of response
• A transvaginal scan including Doppler for arteria ovarica will be performed previously to the surgical procedure.