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Is Plasma Level of Mannose Binding Lectin Associated With Reproductive Failure?

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

A low plasma level of mannose binding lectin (p-MBL) is associated with unexplained recurrent pregnancy loss (RPL), but it is not investigated if it is associated with unexplained reproductive failure in general, including recurrent implantation failure (RIF) after assisted reproductive technology (ART) (including IVF, ICSI and FET), recurrent pregnancy loss (RPL) after spontaneous conception, and RPL after ART.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 41
View:

⁃ fulfil one of the following:

• 3 consecutive pregnancy losses after spontaneous conception

• 3 consecutive pregnancy losses after assisted reproductive technology treatment (ART) including IVF, ICSI and FET

• 3 failed embryo transfers characterized by no achieved pregnancy (after 3 cycles with minimum 1 embryo transfer of a good-quality embryo in each cycle.)

Locations
Other Locations
Denmark
Aagaard Klinik
RECRUITING
Aarhus
Contact Information
Primary
Caroline Noergaard-Pedersen, M.D.
c.noergaardpedersen@rn.dk
+4541120267
Backup
Ole B. Christiansen
olbc@rn.dk
Time Frame
Start Date: 2016-01-01
Estimated Completion Date: 2026-11-30
Participants
Target number of participants: 500
Treatments
Recurrent pregnancy loss after spontaneous conception
Minimum three consecutive losses from pregnancies achieved after spontaneous conception
Recurrent pregnancy loss after assisted reproductive treatment
Minimum three consecutive losses from pregnancies achieved after assisted reproductive treatment (ART), which includes in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and frozen embryo transfer (FER).
Recurrent implantation failure
Minimum three consecutive embryo transfers (ET) of good quality embryos with no hCG production. The patient must not have experienced any clinical pregnancies (i.e. evidence of pregnancy on an US or by histopathological examination) after IVF or spontaneous conception. Biochemical pregnancies after spontaneous conception, which terminated before evidence of a gestational sac on an ultrasonic scan (US) could be visualized and before the series of RIF occurred, are accepted.
Related Therapeutic Areas
Sponsors
Leads: Aalborg University Hospital

This content was sourced from clinicaltrials.gov