Effects of Intrauterine Administration of Autologous Peripheral Blood Mononuclear Cells (PBMC) on the Endometrial Cells Populations

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The behaviour of the endometrium during its receptive phase is highly dependent on the endometrial cell type composition. Each cell type has its role in the endometrial preparation for the invading embryo. Alteration in the immune cells dialogue could be the main reason for unsuccessful implantation in certain patients. Immune cell homeostasis is often improved by intrauterine administration of autologous PBMC. There have been numerous reports on the positive effects of the intrauterine administration of autologous PBMC on the IVF outcomes (embryo implantation and ongoing pregnancy success). However, there is little data on the direct effect of the PBMC administration on the cell composition of the endometrium. This study will focus on the changes in the endometrial cell populations by PBMC treatment that could lead to IVF outcome improvement. The aim of this project is to analyze the effect of intrauterine administration of autologous PBMC on the endometrial cell populations and on the IVF outcome parameters (implantation and ongoing pregnancy success as IVF outcome variables).

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 20
Maximum Age: 50
Healthy Volunteers: f
View:

• Participating in Assisted Reproduction Treatment

• Presenting altered endometrial immune profile

• Having primary infertility

• Having regular menstrual cycles

• Embryo transfer of euploid embryos

Locations
Other Locations
Bulgaria
Medical diagnostic laboratory Imunovita
RECRUITING
Sofia
Nadezhda Women's Health Hospital
RECRUITING
Sofia
Contact Information
Primary
Georgi Stamenov, MD
g.stamenov@abv.bg
+359888269839
Backup
Rumiana Ganeva, MSc
rum.ganeva@gmail.com
+359898484825
Time Frame
Start Date: 2023-12-09
Estimated Completion Date: 2026-12-09
Participants
Target number of participants: 300
Treatments
Experimental: Endometrial cell composition
The cell composition and their quantities will be compared before and after intrauterine administration of PBMC in the endometrial biopsies.
Related Therapeutic Areas
Sponsors
Collaborators: Medical diagnostic laboratory ImunoVita
Leads: Nadezhda Women's Health Hospital

This content was sourced from clinicaltrials.gov