Does Time From Ovulation Trigger To Oocyte Pick-Up Affect Intracytoplasmic Sperm Injection Outcomes? A Multi-Center Single-Blinded Randomized Controlled Trial Comparing 36 and 38 Hour Intervals
Women who undergo assisted reproduction technology (ART) treatment will be eligible for this study. The goal of this randomized clinical trial is to compare the outcomes of ART treatment between women who have 36 and 38 hours interval between the administration of ovulation trigger (ovulation trigger medication initiates oocyte maturation and makes it possible for the egg to be collected by aspiration, during a procedure called oocyte pick-up, OPU) and OPU. The main questions it aims to answer are, does prolonging the trigger-OPU interval to 38-hours improve: 1. Primarily: •Ratio of metaphase-2 oocytes to total number of follicles 2. Secondarily: * Maturation rate * Fertilization rate * Blastulation rate * Premature ovulation rate * Positive pregnancy test rate * Clinical pregnancy rate * Live birth rate compared to 36-hours interval?
• To undergo assisted reproductive technology (ART) treatment and planning to undergo embryo transfer procedure within 6 months of oocyte collection
• Female partner to be between 18-42 years old at the time of informed consent
• Both partners to consent to participate in the study and be legally eligible to give consent.