Efficacy of Oocyte Activation With Two Types of Ca2+ Ionophore: a Prospective Randomized Study.
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study is a prospective ranzomized analysis including 372 human oocytes from 44 women. Half of the oocytes from the same patient will be randomly allocated to induce oocyte activation using two protocols: in protocol nº 1 we will use ionomycin (prepared solution), protocol nª2 A23187 (GM508 CultActive Gynemed) will be applied. Non treated oocytes will serve as control. Oocyte fertilization rates, embryo development and embryo quality will be analyzed. Obstetrics variables of offspring will be also followed and compared.
Eligibility
Participation Requirements
Sex: Female
Healthy Volunteers: f
View:
• Own oocyte patients who have had previous fertilization failure in previous cycles.
• Own oocyte patients with fertilization rate in previous cycles less than or equal to 30% of the microinjected oocytes.
Locations
Other Locations
Spain
Ivirma Valencia
RECRUITING
Valencia
Contact Information
Primary
LAURA CARACENA, Msr
LAURA.CARACENA@IVIRMA.COM
963.050900
Time Frame
Start Date: 2024-01-01
Estimated Completion Date: 2024-12
Participants
Target number of participants: 44
Treatments
Experimental: GROUP 1 IONOMYCIN SIGMA
The oocytes obtained from the patients allocated to this group will be subdivided again in two groups Group 1a: Oocytes treated with SIGMA ionomycin (treatment). Group 1b: Oocytes that will not be treated with any activator (Control).
Active_comparator: GROUP 2 A23187
The oocytes obtained from the patients allocated to this group will be subdivided again in two groups Group 2a: Oocytes treated with A23187 (treatment). Group 2b: Oocytes that will not be treated with any activator (Control).
Related Therapeutic Areas
Sponsors
Leads: Instituto Valenciano de Infertilidad, IVI VALENCIA