Impact of Hyaluronan-enriched Medium on Pregnancy Outcomes Following Euploid Blastocyst Transfers

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

It has been proposed that enriching transfer media with hyaluronan (EmbryoGlue medium) improves pregnancy outcomes compared with media containing lower concentrations of this molecule. However, none of previous studies included preimplantation genetic testing for aneuploidy (PGT-A) embryos. In order to investigate the impact of this hyaluronan-enriched on pregnancy outcomes, it is essential to evaluate its efficacy on euploid-only embryo transfers. The aim of the present study is to evaluate whether a short period of exposure of euploid blastocysts to EmbryoGlue prior to and during transfer positively impact on pregnancy outcomes of frozen embryo transfer (FET) cycles.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 46
Healthy Volunteers: t
View:

• All frozen embryo transfer (FET) cycles with euploid blastocysts biopsied and vitrified on Day 5 after PGT-A.

• Rank of randomization based on embryo quality.

• Only hormonal replacement theraphy (HRT) cycle regimen.

• Women aged 18 years to 46 years.

• Having at least 1 chromosomally normal vitrified blastocyst(s) on Day 5 available for transfer.

• All sperm samples.

• BMI between 18 and 35.

Locations
Other Locations
United Arab Emirates
ART Fertility Clinics LLC
RECRUITING
Abu Dhabi
Contact Information
Primary
Daniela Nogueira
daniela.nogueira@artfertilityclinics.com
+971504374961
Backup
Jonalyn DV Edades, Nursing
jonalyn.edades@artfertilityclinics.com
+97152640866
Time Frame
Start Date: 2024-01-15
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 783
Treatments
No_intervention: Blastocysts exposed to normal media (NEG)
Blastocysts exposed to routine-in use medium No intervention
Active_comparator: Blastocysts exposed to EmbryoGlue (EG)
Blastocysts exposed to EmbryoGlue
Related Therapeutic Areas
Sponsors
Leads: ART Fertility Clinics LLC

This content was sourced from clinicaltrials.gov