Investigation of the Combined Effects of Luteinizing Hormone and Follicle-Stimulating Hormone on Metabolic Regulation in Cumulus Cells
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The combined use of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) has improved IVF pregnancy rates in infertile women aged 35-40, but its mechanisms remain unclear. This prospective study will examine how FSH and LH combined treatment affects cumulus cell energy metabolism. Sixty participants will be divided into two groups receiving either combined therapy or FSH alone. The study will analyze patient characteristics, infertility history, and compare mitochondrial function in cumulus cells to evaluate treatment effectiveness.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 35
Maximum Age: 40
Healthy Volunteers: f
View:
• Age 35-40 years
• BMI 18-30 kg/m2
• planning to undergo IVF cycles
Locations
Other Locations
Taiwan
Kaohsiung Veterans General Hospital
RECRUITING
Kaohsiung City
Contact Information
Primary
Li-Te Lin
litelin1982@gmail.com
+88673464027
Time Frame
Start Date: 2024-12-01
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 60
Treatments
Experimental: combined FSH and LH
Participants receive combined FSH and LH during controlled ovarian stimulation in IVF cycle
Active_comparator: FSH alone
Participants receive combined FSH and LH during controlled ovarian stimulation in IVF cycle
Related Therapeutic Areas
Sponsors
Leads: Kaohsiung Veterans General Hospital.