Trial to Improve Fertilization Rate and Embryo Development in Intracytoplasmic Sperm Injection (ICSI) Cycles
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The Aim of the trial: Assess if a consecutive second ejaculate contains an equal, or even higher number of motile sperm and produces high-quality sperm for intracytoplasmic sperm injection (ICSI) in male factor patients and if it will improve clinical outcomes, such as fertilization rate, embryo quality, number of blastocysts retrieved per cycle, implantation, and hopefully pregnancy rates.
Eligibility
Participation Requirements
Sex: Male
Minimum Age: 25
Maximum Age: 45
Healthy Volunteers: f
View:
• Male: with abnormal semen parameter according to WHO.
• Age range between 25-45 for both partners.
Locations
Other Locations
Egypt
Nour El-Hayat Fertility Center
RECRUITING
Cairo
Contact Information
Primary
Maram Magdy Elbasiony, Master's student
maramagdii@yahoo.com
+201069636357
Backup
Dr.Marwan Osama Elkady, Associate professor
Marwan-elkady@hotmail.com
+201205533315
Time Frame
Start Date: 2024-04-03
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 108
Treatments
Experimental: first ejaculate
In this arm, participants will undergo ICSI using sperm collected from the first ejaculate. Semen analysis will be conducted to assess sperm quality, including motility, morphology, and concentration. This arm will serve as the baseline for comparison with the second ejaculate arm.
Experimental: Second Ejaculate
Participants in this arm will undergo ICSI using sperm collected from the second ejaculate, which will be obtained within a short interval (1-2 hours) after the first. Semen analysis will be conducted to compare sperm quality with that of the first ejaculate, and fertilization and embryo development outcomes will be evaluated
Related Therapeutic Areas
Sponsors
Leads: Ain Shams University