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Characterization of Traditional Medicine Syndromes in Male Infertility With Oligoasthenoteratozoospermia Via Latent Tree Models

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this observational study is to identify and evaluate the characteristics of Traditional Medicine (TM) syndromes in men aged 18 to 60 with male infertility and oligoasthenoteratozoospermia (OAT) syndrome. The main questions it aims to answer are: * What are the common Traditional Medicine syndromes and symptoms associated with male infertility based on Traditional Medicine literature? * What are the specific Traditional Medicine syndromes and symptoms found in men with OAT syndrome at Binh Dan Hospital when analyzed using Latent Tree Models? The research will be conducted in two phases: * Phase 1 (Literature Review): Researchers will collect and analyze Traditional Medicine texts to list the symptoms and syndromes related to male infertility. This phase will help create a standardized clinical survey. * Phase 2 (Clinical Survey): Researchers will recruit 300 male participants with OAT syndrome. * Participants will answer a survey questionnaire about their Traditional Medicine symptoms. * Researchers will apply Latent Tree Models (a mathematical approach) to the collected data to objectively classify the TM syndromes.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: f
View:

• Male patients aged between 18 and 60 years.

• Diagnosed with male infertility by an andrology specialist according to World Health Organization (WHO) standards.

• Semen analysis results meet the diagnostic criteria for Oligoasthenoteratozoospermia (OAT) syndrome.

• Voluntary agreement to participate in the research and signed Informed Consent Form.

Locations
Other Locations
Viet Nam
Binh Dan Hospital
RECRUITING
Ho Chi Minh City
Contact Information
Primary
Minh-Man Pham Bui, PhD
bpmman@uhsvnu.edu.vn
+84916080803
Backup
Dai-Nhan Tran, Medical doctor
nhantd97@gmail.com
+84773478145
Time Frame
Start Date: 2026-01-14
Estimated Completion Date: 2026-09-30
Participants
Target number of participants: 300
Treatments
Male Infertility Patients with OAT Syndrome
* Men aged 18 to 60 years who are diagnosed with male infertility and present with Oligoasthenoteratozoospermia (OAT) syndrome. According to the World Health Organization (WHO) standards, OAT is defined by the following concurrent semen parameters:~ * Oligozoospermia: Sperm concentration \< 15 million/mL or total sperm count \< 39 million.~ * Asthenozoospermia: Progressive motility \< 32%.~ * Teratozoospermia: Normal morphology \< 4%.~* Participants are recruited from the Department of Andrology at Binh Dan Hospital, Ho Chi Minh City. The study excludes individuals with:~ * Genetic or chromosomal abnormalities (e.g., Klinefelter syndrome, XYY syndrome).~ * Structural abnormalities of the reproductive organs.~ * Azoospermia (no sperm in the ejaculate).~ * Recent use (within the last 3 months) of medications known to affect spermatogenesis, such as anabolic steroids or certain calcium channel blockers.~ * Inability to communicate or participate in the survey.
Related Therapeutic Areas
Sponsors
Leads: University of Medicine and Pharmacy at Ho Chi Minh City

This content was sourced from clinicaltrials.gov