Male Fertility Preservation Using Cryopreservation of Testicular Tissue Before Highly Gonadotoxic Cancer Treatment

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Background: Due to the remarkable improvement in treatments these last decades, long term survival can be expected in more than 80% of childhood cancer patients. Unfortunately, cancer treatments can be harmful to the gonads and can affect reproductive and endocrine functions. While loss of fertility is a major concern for most patients, sperm cryopreservation should be offered to all pubertal male patients. For prepubertal boys, only the experimental option of testicular biopsy in order to cryopreserve testicular stem cells can be proposed. Primary aims \- To cryopreserve testicular tissue of prepubertal patient receiving highly gonadotoxic oncological treatment. Secondary aims * To cryopreserve testicular tissue after failure of sperm cryopreservation in pubertal patient with high risk of infertility * To create a database in order to record clinical and biological follow-up data * To create a research biobank for future research projects Multicentric study: HUG, CHUV, UKBB

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 3 months
Maximum Age: 18
Healthy Volunteers: f
View:

• Prepubertal patients aged 3 months and older

• Peri and pubertal patients after failure of sperm cryopreservation

• Patients presenting high risk of infertility because of gonadotoxic treatments (i.e high dose of alkylating agents, testicular irradiation, total body irradiation).

• Multidisciplinary team consensus in favour of proposition to cryopreserve testicular tissue

Locations
Other Locations
Switzerland
UKBB
RECRUITING
Basel
Geneva University Hospitals
RECRUITING
Geneva
CHUV
RECRUITING
Lausanne
Contact Information
Primary
Fabienne Gumy-Pause, Dr
fabienne.gumypause@hcuge.ch
Time Frame
Start Date: 2015-01
Estimated Completion Date: 2100-01
Participants
Target number of participants: 100
Treatments
Experimental: testicular tissue cryopreservation
Sponsors
Leads: Gumy-Pause Fabienne

This content was sourced from clinicaltrials.gov

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