Assessment of Day-night Secretion of Progesterone and LH Across Pubertal Maturation in Girls With and Without Hyperandrogenemia (JCM023)

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Hormones are substances that are made by the body and are sent directly out into the bloodstream to increase or decrease the function of certain organs, glands, or other hormones. Testosterone is a hormone found in the blood of all girls, but some girls have too much testosterone in their blood. Too much testosterone in the blood can possibly lead to a problem called polycystic ovary syndrome (PCOS). People with PCOS have abnormal menstrual periods, excess facial and body hair, and too much testosterone in their blood. On the other hand, some girls with too much testosterone in their blood do not develop PCOS. We do not know why some of these girls develop PCOS and why some do not. The purpose of this research study is to find out whether too much testosterone can cause problems with other hormones that can lead to the development of PCOS. This study may help us understand more about the causes of PCOS.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 7
Maximum Age: 17
Healthy Volunteers: t
View:

• Early and late pubertal girls with normal androgens

• Early and late pubertal girls with hyperandrogenemia

• All subjects will be girls from pre-puberty (Stage 1 breast development and pubic hair growth but at least 7 years old) to 7 years post menarche.

Locations
United States
Virginia
Center for Research in Reproduction, University of Virginia
RECRUITING
Charlottesville
Contact Information
Primary
Melissa Gilrain
pcos@virginia.edu
434-243-6911
Backup
Christopher R. McCartney, MD
cm2hq@virginia.edu
434-243-6911
Time Frame
Start Date: 2008-07-10
Estimated Completion Date: 2025-02
Participants
Target number of participants: 75
Treatments
Hyperandrogenemia
Peripubertal girls with hyperandrogenemia
Controls
Peripubertal girls without hyperandrogenemia
Sponsors
Leads: University of Virginia
Collaborators: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

This content was sourced from clinicaltrials.gov