Learn About Interstitial Keratitis
Interstitial keratitis is inflammation of the tissue of the cornea, the clear window on the front of the eye. This condition can lead to vision loss.
Keratitis interstitial; Cornea - keratitis
Interstitial keratitis is a serious condition in which blood vessels grow into the cornea. Such growth can cause loss of the normal clearness of the cornea. This condition is often caused by infections.
Syphilis is the most common cause of interstitial keratitis, but rare causes include:
- Autoimmune diseases, like rheumatoid arthritis and sarcoidosis
- Leprosy
- Lyme disease
- Tuberculosis
In the United States, most cases of syphilis are recognized and treated before this eye condition develops.
However, interstitial keratitis accounts for 10% of avoidable blindness in the least developed countries worldwide.
Symptoms may include:
- Eye pain
- Excessive tearing
- Sensitivity to light (photophobia)
The underlying disease must be treated. Treating the cornea with corticosteroid drops may minimize scarring and help keep the cornea clear.
Once the active inflammation has passed, the cornea may be left severely scarred and with abnormal blood vessels. The only way to restore vision at this stage is with a cornea transplant.
UPMC Vision Institute
Vishal Jhanji is an Ophthalmologist in Pittsburgh, Pennsylvania. Dr. Jhanji is rated as an Elite provider by MediFind in the treatment of Interstitial Keratitis. His top areas of expertise are Pterygium, Interstitial Keratitis, Keratoconus, Corneal Transplant, and Cataract Removal. Dr. Jhanji is currently accepting new patients.
Regents Of The University Of California
Jeremy Keenan is an Ophthalmologist in San Francisco, California. Dr. Keenan is rated as an Elite provider by MediFind in the treatment of Interstitial Keratitis. His top areas of expertise are Conjunctivitis (Pink Eye), CMV Retinitis, Interstitial Keratitis, Trabeculectomy, and Vitrectomy.
Namrata Sharma practices in New Delhi, India. Ms. Sharma is rated as an Elite expert by MediFind in the treatment of Interstitial Keratitis. Her top areas of expertise are Interstitial Keratitis, Cataract, Stevens-Johnson Syndrome, Corneal Transplant, and Cataract Removal.
Diagnosing and treating interstitial keratitis and its cause early can preserve the clear cornea and good vision.
A corneal transplant is not as successful for interstitial keratitis as it is for most other corneal diseases. The presence of blood vessels in the diseased cornea brings white blood cells to the newly transplanted cornea and increases the risk of rejection.
People with interstitial keratitis need to be followed closely by an ophthalmologist and a medical specialist with knowledge of the underlying disease.
A person with the condition should be checked immediately if:
- Pain gets worse
- Redness increases
- Vision decreases
This is particularly crucial for people with corneal transplants.
Prevention consists of avoiding the infection that causes interstitial keratitis. If you do get infected, get prompt and thorough treatment and follow-up.
Summary: The goal of this clinical trial is to learn if adjunctive topical Cyclosporine A eye drops combined with standard of care topical Natamycin treatment improves vision outcomes in patients with fungal keratitis.
Summary: The purpose of this randomized, controlled, multicenter study is to evaluate the safety and efficacy of TTAX03 in participants with mild to moderate DED. The primary question it aims to answer is if TTAX03 is safe. The secondary is the effectiveness. Researchers will compare 10mg of TTAX03 reconstituted in 150, 300, or 600 uL saline to the saline control group to look at effectiveness. Participant...
Published Date: July 09, 2024
Published By: Audrey Tai, DO, MS, Athena Eye Care, Mission Viejo, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Gauthier A-S, Noureddine S, Delbosc B. Interstitial keratitis diagnosis and treatment. J Fr Ophtalmol. 2019;42(6):e229-e237. PMID: 31103357 pubmed.ncbi.nlm.nih.gov/31103357/.
Starnes TW, Vasaiwala RA, Bouchard CS. Noninfectious keratitis. In: Yanoff M, Duker JS, eds. Ophthalmology. 6th ed. Philadelphia, PA: Elsevier; 2023:chap 4.17.
World Health Organization website. Eye care, vision impairment and blindness. www.who.int/health-topics/blindness-and-vision-loss#tab=tab_1. Accessed August 9, 2024.