Assessment of Pupillary Response and Visual Field Defects by Objective Multifocal Chromatic Pupillometer in Patients With Pseudotumor Cerebri and Healthy Subjects
PTC(Pseudotumor cerebri) patients may develop increased Intracranial pressure (ICP) that can produces increased pressure around the distal optic nerve,which is likely followed by venule compression, ischemia, and loss of visual function.Vision loss in PTC is most commonly characterized by standard automated perimetry to measure peripheral visual field sensitivity. Pupillometry is a promising approach for functional assessment in PTC because it is noninvasive, objective, performed quickly with minimal patient cooperation needed. The feasibility of using chromatic multifocal pupillometry for assesment of PTC will be examined.
∙ Healthy subjects
• Male or female patients, age between 18 and 80 years, inclusive
• Informed written consent will be obtained from all participants.
• Normal eye examination
• Best-corrected visual acuity (BCVA) of 20/20
• Normal color vision test (Ishihara/HRR)
• Normal Spectral-Domain Optical Coherence Tomography (SD-OCT)
• Normal 24-2 Humphrey visual field (SITA Standard) and:
‣ Short duration (≤10 minutes)
⁃ Minimal fixation losses, False POS errors and False NEG errors (less than 33% for each one of reliability indices)
∙ PTC patients
• Male or female patients, age between 18 and 80 years, inclusive
• Best-corrected visual acuity (BCVA) of at least 20/100 in worse eye
• Optic disc edema
• PTC diagnosis based on Modified Dandy Criteria ( lumbar puncture with opening pressure higher than or equal to 25 cm H2O, normal cerebrospinal fluid constituents, and unremarkable brain imaging results except typical for PTC