Learn About Intraductal Papilloma

What is the definition of Intraductal Papilloma?

Intraductal papilloma is a small, noncancerous (benign) tumor that grows in a milk duct of the breast.

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What are the causes of Intraductal Papilloma?

Intraductal papilloma occurs most often in women ages 35 to 55. The causes and risk factors are unknown.

What are the symptoms of Intraductal Papilloma?

Symptoms include:

  • Breast lump
  • Nipple discharge, which may be clear or bloodstained

These findings may be in just one breast or in both breasts.

For the most part, these papillomas do not cause pain.

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What are the current treatments for Intraductal Papilloma?

If there is nipple discharge, the duct is removed with surgery if imaging did not show a lump that can be checked with a needle biopsy. If a needle biopsy shows an intraductal papilloma, the papilloma may be removed with surgery, or watched over time with exams and imaging.

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What is the outlook (prognosis) for Intraductal Papilloma?

For the most part, intraductal papillomas do not appear to increase the risk of developing breast cancer.

The outcome is excellent for people with one papilloma. The risk for cancer may be higher for:

  • Women with many papillomas
  • Women who get them at an early age
  • Women with a family history of cancer
  • Women who have abnormal cells in the biopsy
What are the possible complications of Intraductal Papilloma?

Complications of surgery can include bleeding, infection, scarring, and anesthesia risks. If the biopsy shows cancer, you may need further surgery and treatment.

When should I contact a medical professional for Intraductal Papilloma?

Call your provider if you notice any breast discharge or a breast lump.

How do I prevent Intraductal Papilloma?

There is no known way to prevent intraductal papilloma. Breast self-exams and screening mammograms can help detect the disease early.

Intraductal papilloma
Abnormal discharge from the nipple
Core needle biopsy of the breast
What are the latest Intraductal Papilloma Clinical Trials?
The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed With Intraductal Papilloma Without Atypia or Flat Epithelial Atypia by Core Needle Biopsy

Summary: This research study is studying a surgical intervention to rule out the presence of cancer in participants that have been diagnosed with flat epithelial atypia (FEA) or intraductal papilloma without atypia (IPWA) by core needle biopsy.

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Feasibility and Therapeutic Efficacy of Ductoscopic Papilloma Extraction in Patients With Pathologic Nipple Discharge

Summary: In this prospective clinical trial, patients who sign an approved informed consent for ductoscopy to assess etiology of Pathologic nipple discharge (PND) will be enrolled in the study. Consented patients who have been diagnosed with a solitary papilloma within the discharging duct will be recruited to have interventional ductoscopy. Patients who are identified ductoscopically with a solitary non-s...

What are the Latest Advances for Intraductal Papilloma?
A Case of Intraductal Papilloma of the Male Breast.
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Bloody nipple discharge in Carney complex: A case report.
Who are the sources who wrote this article ?

Published Date: November 06, 2021
Published By: Debra G. Wechter, MD, FACS, General Surgery Practice Specializing in Breast Cancer, Virginia Mason Medical Center, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Davidson NE. Breast cancer and benign breast disorders. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 188.

Klimberg VS, Hunt KK. Diseases of the breast.  In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 21st ed. Philadelphia, PA: Elsevier; 2022:chap 35.

Sasaki J, Geletzke, Kass RB, Klimberg VS, et al. Etiology and management of benign breast disease. In: Bland KI, Copeland EM, Klimberg VS, Gradishar WJ, eds. The Breast: Comprehensive Management of Benign and Malignant Disorders. 5th ed. Philadelphia, PA: Elsevier; 2018:chap 5.