Intrahepatic Cholestasis of PregnancySymptoms, Doctors, Treatments, Advances & More
Learn About Intrahepatic Cholestasis of Pregnancy
Intrahepatic cholestasis of pregnancy (also called ICP) is a liver disorder that typically occurs during the second half of pregnancy. Cholestasis is a condition that impairs the release of a digestive fluid called bile, which is made and released by the liver. In people with cholestasis, bile builds up in the liver, impairing its function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis.
Intrahepatic cholestasis of pregnancy is a complex disorder. It is believed to be caused by a combination of genetic, hormonal, and environmental factors. Risk factors for developing intrahepatic cholestasis of pregnancy include underlying liver disease and a form of diabetes called gestational diabetes that occurs during pregnancy. Being pregnant with more than one baby or having a history of intrahepatic cholestasis of pregnancy also increases the risk of developing this condition. Sometimes, more than one person in a family has this condition.
Intrahepatic cholestasis of pregnancy is the most common liver disease related to pregnancy. It is estimated to affect up to 2 percent of pregnancies, although the number of people affected varies by country and population. The condition is more common in South America and northern Europe. Historically, the highest incidence occurred in the Araucanian Indian population in Chile, although the incidence in this population has declined in recent years.
An increased susceptibility to intrahepatic cholestasis of pregnancy typically has an autosomal dominant pattern of inheritance, which means one copy of the altered gene in each cell is sufficient to increase the risk of developing the disorder.
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Lauren Ferrara is a Neonatologist and an Obstetrics and Gynecologist practicing medicine in New York, New York. Dr. Ferrara is rated as an Elite provider by MediFind in the treatment of Intrahepatic Cholestasis of Pregnancy. She is also highly rated in 8 other conditions, according to our data. Her clinical expertise encompasses Intrahepatic Cholestasis of Pregnancy, Placenta Previa, Methimazole Antenatal Exposure, Intrauterine Device Insertion, and Hormone Replacement Therapy (HRT).
Olson Center For Women's Health At Durham Outpatient Center
Maggie Kuhlmann is a Neonatologist practicing medicine in Omaha, Nebraska. She has been practicing medicine for over 13 years. Dr. Kuhlmann is rated as an Advanced provider by MediFind in the treatment of Intrahepatic Cholestasis of Pregnancy. She is also highly rated in 9 other conditions, according to our data. Her clinical expertise encompasses Preeclampsia, Premature Infant, Vaginal Bleeding in Pregnancy, and ABO Incompatibility.
Caroline Ovadia practices practicing medicine in London, United Kingdom. Ms. Ovadia is rated as an Elite expert by MediFind in the treatment of Intrahepatic Cholestasis of Pregnancy. She is also highly rated in 3 other conditions, according to our data. Her clinical expertise encompasses Intrahepatic Cholestasis of Pregnancy, Cholestasis, Bile Duct Obstruction, and Biliary Hypoplasia.
Summary: The goal of this observational study is to learn if analyzing bile acid patterns can help predict dangerous complications in pregnant women with intrahepatic cholestasis of pregnancy (ICP), a liver condition that can affect the baby. The main questions it aims to answer are: * Can measuring specific types of bile acids (particularly taurine-conjugated versus glycine-conjugated bile acids) in the m...
Summary: This observational prospective study will help to determine if an immune process similar to allograft rejection is responsible for the occurrence of an intrahepatic cholestasis of pregnancy (ICP). If so, it would suggest the potential benefit of immunomodulatory therapeutics.
Published Date: April 25, 2024
Published By: National Institutes of Health