Iron Deficiency Anemia Clinical Trials

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The Impact of Faba Bean Rich Bread on Iron Status, Postprandial Lipaemia and Satiety in Adults with Low Iron Stores

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

High levels of animal proteins (meat) in the diet are linked with a greater risk of developing heart disease and other long-term health conditions. Recently there has been a shift to plant-based diets including plant proteins such as pulses, defined as beans, peas, chickpeas and lentils. Pulses are a nutritious and sustainable form of plant protein which are rich in fibre and iron. Despite this, the UK population does not consume the recommended daily amount of pulses (80g/day equivalent to a large handful). In contrast, bread is commonly consumed but very little is known about how bread enriched with pulses influences the amount of iron that is digested and absorbed by the body as well as risk factors for developing heart disease and type 2 diabetes. The main purpose of this randomised controlled cross-over study is to determine how consuming bread enriched with pulses (in the form of faba bean flour at approximately 40% enrichment) compared with conventional white bread (100% wheat flour) influences the amount of iron absorbed in healthy males and females aged 18-50 years with low iron stores. Secondary aims are determining the effects on blood fats and sugar (glucose) and on feelings of fullness (also known as satiety) after eating the bread enriched in pulses and conventional white bread. Participants will be required: * To attend for seven study visits over a period of 60 days. * Consume a breakfast meal containing either the faba bean-enriched bread or conventional bread over two study periods, each consisting of one 7 hour study visit and two consecutive visits of 2 hours in duration. After 28 days, participants will return for the second study period as above, with a final study visit conducted 28 days later. * Give blood samples during 2 x 7 hour study visits * Complete visual analogue scales to rate appetite after consuming the faba bean-enriched and conventional white bread. * Record dietary intake prior to and during the study period.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: t
View:

• Non-anaemic, males and pre-menopausal females (must have regular periods)

• Aged 18-50 years old

• BMI between 19 - 30 kg/m2

• Low iron stores (serum ferritin between 13-40 µg/L for females and 30-90 µg/L for males)

Locations
Other Locations
United Kingdom
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading
RECRUITING
Reading
Contact Information
Primary
Julie A Lovegrove, BSc PhD
j.a.lovegrove@reading.ac.uk
011 44 118 378 6418
Backup
Kim G Jackson, BSc PhD
k.g.jackson@reading.ac.uk
011 44 118 378 5361
Time Frame
Start Date: 2024-09
Estimated Completion Date: 2025-09
Participants
Target number of participants: 16
Treatments
Active_comparator: Faba bean-enriched bread.
100 g of bread prepared using 40% faba bean flour and 60% wheat flour will be provided in the breakfast test meal.
Placebo_comparator: Conventional white bread
100 g of white bread prepared using 100% wheat flour will be provided in the breakfast test meal.
Related Therapeutic Areas
Sponsors
Collaborators: University of Leeds, King's College London
Leads: University of Reading

This content was sourced from clinicaltrials.gov

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