Isolated Duane Retraction Syndrome Overview
Learn About Isolated Duane Retraction Syndrome
Isolated Duane retraction syndrome is a disorder of eye movement. This condition prevents outward movement of the eye (toward the ear), and in some cases it may also limit inward eye movement (toward the nose). In people with this condition, the eyeball pulls back (retracts) into its socket and the eyelid opening narrows as the eye moves inward. Due to these movement limitations, the eyes often do not look in the same direction (strabismus). Instead, affected individuals may need to turn their head to track objects with both eyes.
In most people with isolated Duane retraction syndrome, the cause of the condition is unknown. However, researchers have identified variants (also called mutations) in the CHN1 gene that cause the disorder in some affected individuals.
Isolated Duane retraction syndrome is estimated to affect 1 in 1,000 to 10,000 people worldwide. This condition accounts for 1 percent to 5 percent of all cases of strabismus.
Isolated Duane retraction syndrome usually occurs in people with no history of the disorder in their family. These cases are described as simplex, and their genetic cause is unknown.
University Of Pittsburgh Physicians
Preeti Patil is an Ophthalmologist in Pittsburgh, Pennsylvania. Dr. Patil and is rated as an Experienced provider by MediFind in the treatment of Isolated Duane Retraction Syndrome. Her top areas of expertise are Strabismus, Isolated Duane Retraction Syndrome, Duane-Radial Ray Syndrome, and Brown Syndrome.
The Milton S Hershey Medical Center Physicians Group
William Cantore is an Ophthalmologist in Hershey, Pennsylvania. Dr. Cantore and is rated as an Experienced provider by MediFind in the treatment of Isolated Duane Retraction Syndrome. His top areas of expertise are Optic Nerve Atrophy, Optic Atrophy Type 1, Strabismus, and Graves Disease.
Eye Associates
Rebecca Walker is an Ophthalmologist in Chalfont, Pennsylvania. Dr. Walker and is rated as an Experienced provider by MediFind in the treatment of Isolated Duane Retraction Syndrome. Her top areas of expertise are Glaucoma, Cataract, Isolated Duane Retraction Syndrome, and Late-Onset Retinal Degeneration.
Summary: The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.
Published Date: May 31, 2024
Published By: National Institutes of Health