Juvenile Paget's DiseaseSymptoms, Doctors, Treatments, Advances & More
Juvenile Paget's Disease Overview
Learn About Juvenile Paget's Disease
Juvenile Paget disease is a disorder that affects bone growth. This disease causes bones to be abnormally large, misshapen, and easily broken (fractured). The specific signs and symptoms and the severity of the condition can vary among affected individuals.
Variants (also called mutations) in the TNFRSF11B gene cause juvenile Paget disease. This gene provides instructions for making a protein that is involved in bone remodeling, a normal process in which old bone is broken down and replaced by new bone. Bones are constantly being remodeled, and the process is carefully controlled to ensure that bones stay strong and healthy.
Juvenile Paget disease is extremely rare; approximately 100 affected individuals have been reported in the medical literature.
Juvenile Paget disease is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell must have a variant to cause the disorder. The parents of an individual with an autosomal recessive condition each carry one copy of the altered gene, but they typically do not show signs and symptoms of the condition.
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Michael Whyte is a primary care provider, practicing in Internal Medicine in Saint Louis, Missouri. Dr. Whyte is rated as an Elite provider by MediFind in the treatment of Juvenile Paget's Disease. He is also highly rated in 28 other conditions, according to our data. His clinical expertise encompasses Hypophosphatasia (HPP), Juvenile Paget's Disease, Rickets, Osteopetrosis, and Leg or Foot Amputation. Dr. Whyte is currently accepting new patients.
Tim Cundy practices practicing medicine in Grafton, New Zealand. Mr. Cundy is rated as an Elite expert by MediFind in the treatment of Juvenile Paget's Disease. He is also highly rated in 11 other conditions, according to our data. His clinical expertise encompasses Juvenile Paget's Disease, Paget's Disease of Bone, Camurati-Engelmann Disease, and Congenital Bowing of Long Bones.
Stergios Polyzos practices practicing medicine in Thessaloniki, Greece. Polyzos is rated as an Elite expert by MediFind in the treatment of Juvenile Paget's Disease. They are also highly rated in 19 other conditions, according to our data. Their clinical expertise encompasses Juvenile Paget's Disease, Non-Alcoholic Fatty Liver Disease, Helicobacter Pylori Infection, Hormone Replacement Therapy (HRT), and Sleeve Gastrectomy.
Published Date: November 20, 2025
Published By: National Institutes of Health