Kallikrein Hypertension Latest Advances

Kidney kallikrein-1 contributes to cleavage of gamma-ENaC in vivo.

Journal: bioRxiv : the preprint server for biology

Published: September 26, 2025

KLK8: charting new territories in left ventricular hypertrophy biomarker research.

Journal: Biomarkers in medicine

Published: April 02, 2025

A Phase 1C, Open Label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of DM199 Administered Intravenously with a Polyvinyl Chloride Bag in Adult Healthy Subjects and Adults Recently Taking Angiotensin-Converting Enzyme Inhibitors.

Journal: Clinical pharmacology in drug development

Published: January 06, 2025

Role of human urinary kallikrein in reducing progressive ischemic stroke among acute ischemic stroke patients with concurrent hypertension and diabetes: a hospital-based retrospective cohort study.

Journal: Frontiers in neurology

Published: October 31, 2024

Tissue Kallikrein as a Mediator in Stroke Outcomes among Patients With Metabolic Syndrome: A Multicenter Study Integrating Big Data and Biomarkers.

Journal: MedComm

Published: October 15, 2024

Effect of Various Fruit Extracts on Angiotensin I-Converting Enzyme (ACE) and Kallikrein (KLK) Activities.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands)

Published: August 05, 2024

Bradykinin deficiency causes high blood pressure in mice.

Journal: Biochemical and biophysical research communications

Published: August 21, 2023

Dysregulation of kidney proteases in the pathogenesis of hypertension following unilateral nephrectomy in juvenile mice.

Journal: American journal of translational research

Published: June 30, 2023

Behavior of the renal kallikrein in spontaneously hypertensive rats: Influence of sexual hormones and aldosterone-sensitive distal nephron ion channels.

Journal: Peptides

Published: September 26, 2022

Decreased Tissue Kallikrein Levels and the Risk of Ischemic Stroke: A Community-Based Cross-Sectional Study in China.

Journal: Journal of inflammation research

Published: October 12, 2021

The innate immune response, microenvironment proteinases, and the COVID-19 pandemic: pathophysiologic mechanisms and emerging therapeutic targets.

Journal: Kidney international supplements

Published: August 27, 2021

Proteomics discovery of pulmonary hypertension biomarkers: Insulin-like growth factor binding proteins are associated with disease severity.

Journal: Pulmonary circulation

Published: August 05, 2021