Learn About Kaposi Sarcoma

What is the definition of Kaposi Sarcoma?

Kaposi sarcoma (KS) is a cancerous tumor of the connective tissue.

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What are the alternative names for Kaposi Sarcoma?

Kaposi's sarcoma; HIV - Kaposi; AIDS - Kaposi

What are the causes of Kaposi Sarcoma?

KS is the result of infection with a gamma herpesvirus known as Kaposi sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8). It is in the same family as the Epstein-Barr virus, which causes mononucleosis.

KSHV is transmitted mainly through saliva. It can also be spread through sexual contact, blood transfusion, or transplants. After it enters the body, the virus can infect different kinds of cells, especially cells that line blood vessels and lymphatic vessels. Like all herpesviruses, KSHV remains in your body for the rest of your life. If your immune system becomes weakened in the future, this virus may have the chance to reactivate, causing symptoms.

There are four types of KS based on the groups of people who are infected:

  • Classic KS: Mainly affects older men of Eastern European, Middle Eastern, and Mediterranean descent. The disease usually develops slowly.
  • Epidemic (AIDS-related) KS: Occurs most often in people who have HIV infection and have developed AIDS.
  • Endemic (African) KS: Mainly affects people of all ages in Africa.
  • Immunosuppression-associated, or transplantation-associated, KS: Occurs in people who have had an organ transplant and are medicines that suppress their immune system.
What are the symptoms of Kaposi Sarcoma?

The tumors (lesions) most often appear as bluish-red or purple bumps on the skin. They are reddish-purple because they are rich in blood vessels.

The lesions may first appear on any part of the body. They also can appear inside the body. Lesions inside the body may bleed. Lesions in the lungs can cause bloody sputum or shortness of breath.

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What are the current treatments for Kaposi Sarcoma?

How KS is treated depends on:

  • How much the immune system is suppressed (immunosuppression)
  • Number and location of the tumors
  • Symptoms

Treatments include:

  • Antiviral therapy against HIV, since there is no specific therapy for HHV-8
  • Combination chemotherapy
  • Freezing the lesions
  • Radiation therapy

Lesions may return after treatment.

Who are the top Kaposi Sarcoma Local Doctors?
Highly rated in
Internal Medicine

Bethesda, MD 20892

Kathryn Lurain is an Internal Medicine doctor in Bethesda, Maryland. Dr. Lurain is rated as an Elite doctor by MediFind in the treatment of Kaposi Sarcoma. She is also highly rated in 6 other conditions, according to our data. Her top areas of expertise are Kaposi Sarcoma, Multicentric Castleman Disease, Castleman Disease, and Lymphoid Hyperplasia. She is licensed to treat patients in Illinois.

Highly rated in

Makerere University

Kampala, C, UG 

Aggrey Semeere is in Kampala, Uganda. Semeere is rated as an Elite expert by MediFind in the treatment of Kaposi Sarcoma. They are also highly rated in 3 other conditions, according to our data. Their top areas of expertise are Kaposi Sarcoma, Adult Soft Tissue Sarcoma, HIV/AIDS, and Sudden Infant Death Syndrome.

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Highly rated in

Mass General Brigham

Dermatology Associates

50 Staniford St 
Boston, MA 2114

Esther Freeman is a Dermatologist in Boston, Massachusetts. Dr. Freeman has been practicing medicine for over 16 years and is rated as an Elite doctor by MediFind in the treatment of Kaposi Sarcoma. She is also highly rated in 6 other conditions, according to our data. Her top areas of expertise are Kaposi Sarcoma, Perniosis, Frostbite, and Pityriasis Rosea. She is board certified in Dermatology and licensed to treat patients in Massachusetts. Dr. Freeman is currently accepting new patients.

What is the outlook (prognosis) for Kaposi Sarcoma?

Treating KS does not improve the chances of survival from HIV/AIDS itself. The outlook depends on the person's immune status and how much of the HIV virus is in their blood (viral load). If the HIV is controlled with medicine, the lesions will often shrink away on their own.

What are the possible complications of Kaposi Sarcoma?

Complications can include:

  • Cough (possibly bloody) and shortness of breath if the disease is in the lungs
  • Leg swelling that may be painful or cause infections if the disease is in the lymph nodes of the legs

The tumors can return even after treatment. KS can be deadly for a person with AIDS.

An aggressive form of endemic KS can spread quickly to the bones. Another form found in African children does not affect the skin. Instead, it spreads through the lymph nodes and vital organs, and can quickly become deadly.

How do I prevent Kaposi Sarcoma?

Safer sexual practices can prevent HIV infection. This prevents HIV/AIDS and its complications, including KS.

KS almost never occurs in people with HIV/AIDS whose disease is well controlled.

Kaposi sarcoma - lesion on the foot
Kaposi sarcoma on the back
Kaposi sarcoma - close-up
Kaposi sarcoma on the thigh
Kaposi sarcoma - perianal
Kaposi sarcoma on foot
What are the latest Kaposi Sarcoma Clinical Trials?
Phase I Study of MK-3475 (Pembrolizumab) in Patients With Human Immunodeficiency Virus (HIV) and Relapsed/Refractory or Disseminated Malignant Neoplasm
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A Phase II Study of sEphB4-HSA in Kaposi Sarcoma
What are the Latest Advances for Kaposi Sarcoma?
PD-1 blockade with pembrolizumab in classic or endemic Kaposi's sarcoma: a multicentre, single-arm, phase 2 study.
Study of 172 Cases of AIDS Associated Cancers.
Tired of the same old research?
Check Latest Advances
Cryotherapy Treatment of Cutaneous Kaposi Sarcoma in a Patient With B-Cell Chronic Lymphocytic Leukemia: A Case Report and Short Review of the Literature.
Who are the sources who wrote this article ?

Published Date : December 24, 2020
Published By : Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Kaye KM. Kaposi sarcoma-associated herpesvirus (human herpesvirus 8). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 140.

Merrick ST, Jones S, Glesby MJ. Systemic manifestations of HIV/AIDS. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 366.

National Cancer Institute website. Kaposi sarcoma treatment (PDQ) - health professional version. www.cancer.gov/types/soft-tissue-sarcoma/hp/kaposi-treatment-pdq. Updated July 27, 2018. Accessed February 18, 2021.