What is the definition of Kartagener Syndrome?
Kartagener syndrome is a type of primary ciliary dyskinesia that is also characterized by situs inversus totalis (mirror-image reversal of internal organs). The signs and symptoms vary but may include neonatal respiratory distress; frequent lung, sinus and middle ear infections beginning in early childhood; and infertility. It can be cause by changes (mutations) in many different genes that are inherited in an autosomal recessive manner. Although scientists have identified many of the genes associated with Kartagener syndrome, the genetic cause of some cases is unknown. There is no cure for Kartagener syndrome. Treatment varies based on the signs and symptoms present in each person but may include airway clearance therapy and antibiotics.
What are the alternative names for Kartagener Syndrome?
- Dextrocardia bronchiectasis and sinusitis
- Siewert syndrome
- Immotile cilia syndrome, Kartagener type
- Primary ciliary dyskinesia, Kartagener type
- Dextrocardia-bronchiectasis-sinusitis syndrome
- Primary ciliary dyskinesia and situs inversus
What are the causes for Kartagener Syndrome?
Kartagener syndrome can be caused by changes (mutations) in many different genes. These genes encode proteins that are important to the structure and function of cilia. Cilia are tiny, hair-like structures that are found on the surface of cells in various parts of the body such as the lining of the airway, the reproductive system, and other organs. The coordinated movement of cilia in wave-like motions is important to the normal functioning of certain organs and tissues throughout the body and ensures the proper placement of organs in the developing embryo. Mutations in these genes cause the cilia to be either immotile (unable to move) or dysmotile (they move incorrectly), which leads to the many signs and symptoms of Kartagener syndrome.
Scientists have identified several different genes that are associated with Kartagener syndrome; however, the genetic cause is unknown in some cases.
What are the symptoms for Kartagener Syndrome?
Kartagener syndrome is characterized by primary ciliary dyskinesia
and situs inversus totalis. In people affected by situs inversus totalis, the internal organs including the heart, liver, spleen and intestine are on the opposite side of the body. Although the internal organs are abnormally placed, this condition typically does not cause any health problems.
The signs and symptoms of primary ciliary dyskinesia vary, but may include:
- Neonatal respiratory distress
- Frequent respiratory infections that can lead to severe lung damage
- Chronic nasal congestion
- Frequent sinus infections
- Recurrent middle ear infections, particularly in early childhood
- Hearing loss
What are the current treatments for Kartagener Syndrome?
There is currently no cure for Kartagener syndrome. Treatment varies based on the signs and symptoms present in each person. Airway clearance therapy, similar to that used in cystic fibrosis, can loosen thick, sticky mucus so it can be cleared away. Antibiotics may be prescribed to treat respiratory, sinus, and middle ear infections and may be given on a long-term basis in people with chronic or frequent infections. Surgery to insert ear tubes may be recommended in children with chronic ear infections that are resistant to antibiotics. In people with severe lung disease, lung transplantation may be an option.
For more information on the treatment and management of Kartagener syndrome, please click here.
What is the outlook (prognosis) for Kartagener Syndrome?
The long-term outlook for people with Kartagener syndrome varies widely and largely depends on timely diagnosis and treatment. Chronic childhood infections can be very debilitating. However, with appropriate treatment, the progression of lung disease can be slowed and other complications such as hearing loss can be avoided.
Is Kartagener Syndrome an inherited disorder?
Kartagener syndrome is inherited in an autosomal recessive manner. This means that to be affected, a person must have a mutation in both copies of the responsible gene in each cell. The parents of an affected person usually each carry one mutated copy of the gene and are referred to as carriers. Carriers typically do not show signs or symptoms of the condition. When two carriers of an autosomal recessive condition have children, each child has a 25% (1 in 4) risk to have the condition, a 50% (1 in 2) risk to be a carrier like each of the parents, and a 25% chance to not have the condition and not be a carrier.