Kawasaki disease is a sudden and time-limited (acute) illness that affects infants and young children. Affected children develop a prolonged fever lasting several days, a skin rash, and swollen lymph nodes in the neck (cervical lymphadenopathy). They also develop redness in the whites of the eyes (conjunctivitis) and redness (erythema) of the lips, lining of the mouth (oral mucosa), tongue, palms of the hands, and soles of the feet.
The causes of Kawasaki disease are not well understood. The disorder is generally regarded as being the result of an abnormal immune system activation, but the triggers of this abnormal response are unknown. Because cases of the disorder tend to cluster geographically and by season, researchers have suggested that an infection may be involved. However, no infectious agent (such as a virus or bacteria) has been identified.
In the United States and other Western countries, Kawasaki disease occurs in approximately 1 in 10,000 children under 5 each year. The condition is 10 to 20 times more common in East Asia, including Japan, Korea, and Taiwan.
A predisposition to Kawasaki disease appears to be passed through generations in families, but the inheritance pattern is unknown. Children of parents who have had Kawasaki disease have twice the risk of developing the disorder compared to the general population. Children with affected siblings have a tenfold higher risk.
Jane Burns is a Pediatrics expert in San Diego, California. Burns is rated as an Elite expert by MediFind in the treatment of Kawasaki Disease. She is also highly rated in 3 other conditions, according to our data. Her top areas of expertise are Kawasaki Disease, Multisystem Inflammatory Syndrome in Children (MIS-C), Pediatric Myocarditis, Emphysema, and Coronary Artery Bypass Graft (CABG). She is licensed to treat patients in California. Burns is currently accepting new patients.
Adriana Tremoulet is a Pediatric Infectious Disease specialist and a Pediatrics expert in San Diego, California. Tremoulet has been practicing medicine for over 23 years and is rated as an Elite expert by MediFind in the treatment of Kawasaki Disease. She is also highly rated in 4 other conditions, according to our data. Her top areas of expertise are Kawasaki Disease, Multisystem Inflammatory Syndrome in Children (MIS-C), Pediatric Myocarditis, and Infectious Myocarditis. She is licensed to treat patients in California. Tremoulet is currently accepting new patients.
Nagib Dahdah practices in Montreal, Canada. Dahdah is rated as an Elite expert by MediFind in the treatment of Kawasaki Disease. They are also highly rated in 10 other conditions, according to our data. Their top areas of expertise are Kawasaki Disease, Coronary Artery Aneurysm, Vasculitis, Heart Bypass Surgery, and Percutaneous Coronary Intervention (PCI).
Summary: To evaluate the efficacy and safety of rivaroxaban compared to warfarin for thromboprophylaxis in children with giant coronary aneurysms after Kawasaki disease
Summary: Kawasaki disease (KD) is an acute self-limited vasculitis of infancy and early childhood. Most patients recover without sequelae although the inflammatory process causes permanent damage to the coronary arteries in 20-25% of untreated children. An infectious aetiology is suspected, but the causative agent has not been identified. The investigators aim to identify the genes underlying both suscepti...
Published Date: September 01, 2015Published By: National Institutes of Health