Inflammation and Insulin Resistance in Kidney Stone Patients

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

This observational study aims to look at the connections between kidney stones, insulin resistance, and inflammation. The researchers hypothesize that people who form calcium kidney stones and have insulin resistance may have higher levels of inflammation because they have more visceral fat (fat around the abdominal organs). The study will recruit 20 people who have had calcium kidney stones but don't have diabetes, and 20 healthy people who haven't had kidney stones. All the participants will come to the research center at the University of Chicago Medicine. Participants will have a dual-energy X-ray absorptiometry (DEXA) scan to measure their visceral fat, and give blood and urine samples. The blood will be tested for insulin resistance, inflammatory markers, and other metabolic factors. The urine will be analyzed for substances that increase kidney stone risk. The main goal is to see if the kidney stone formers with insulin resistance have more visceral fat compared to those without insulin resistance and the healthy participants. The researchers will also compare inflammatory marker levels between groups, and look at how visceral fat, inflammatory markers, insulin resistance, and urine stone risk factors are related. The findings may help explain how kidney stones are connected to metabolic conditions like diabetes and cardiovascular disease. Researchers hope this information will help identify stone formers at risk early and develop preventive treatments in the future.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:

• Stone formers:

• Age 18-70

• History of at least one calcium-based kidney stone

• Healthy Controls:

• Age 18-70

• No history of kidney stone or family history of kidney stones

Locations
United States
Illinois
University of Chicago Medical Center
RECRUITING
Chicago
Contact Information
Primary
Megan Prochaska, MD
mprocha2@medicine.bsd.uchicago.edu
773-702-1000
Backup
Elaine Worcester, MD
eworcest@medicine.bsd.uchicago.edu
773-702-3630
Time Frame
Start Date: 2024-06-30
Estimated Completion Date: 2026-08-01
Participants
Target number of participants: 40
Treatments
Kidney stone formers
The study team plans to enroll 20 non-diabetic participants with a history of at least one calcium-based kidney stone. Activities are the same for both cohorts, as follows:~* Before clinic visit, participants will halt specific supplements and diuretics for a week.~* At home, they complete a dietary questionnaire and collect 24-hour urine.~* On the 7th day, they visit University of Chicago CRC. There, investigators will take measurements (height, weight) and DEXA scan, alongside kidney stone history review.~* Throughout the day, participants provide urine and blood samples, undergo blood pressure checks, and fast until sample collection.~* Samples undergo testing for kidney stone, inflammation, and diabetes risk factors and are stored for future research.
Control cohort
The study team plans to enroll 20 healthy control participants with no history of kidney stones or family history of kidney stones. Activities are the same for both cohorts, as follows:~* Before clinic visit, participants will halt specific supplements and diuretics for a week.~* At home, they complete a dietary questionnaire and collect 24-hour urine.~* On the 7th day, they visit University of Chicago CRC. There, investigators will take measurements (height, weight) and DEXA scan, alongside kidney stone history review.~* Throughout the day, participants provide urine and blood samples, undergo blood pressure checks, and fast until sample collection.~* Samples undergo testing for kidney stone, inflammation, and diabetes risk factors and are stored for future research.
Related Therapeutic Areas
Sponsors
Leads: University of Chicago

This content was sourced from clinicaltrials.gov