Oxalate and Citrate in Humans - Response to Citrate
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person's chances of forming kidney stones. The study will examine changes in urinary oxalate and citrate levels after participants consume potassium citrate.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:
⁃ Stone formers (SF):
• Age 18-70
• History of at least one calcium-based kidney stone
⁃ Non-stone formers (NSF):
• Age 18-70
• No history of kidney stone
• 24-hour urine oxalate within laboratory normal range (\<50 mg/day)
Locations
United States
Illinois
University of Chicago Medical Center
RECRUITING
Chicago
Time Frame
Start Date: 2025-10-01
Estimated Completion Date: 2027-06-01
Participants
Target number of participants: 24
Treatments
Other: Kidney stone formers
12 stone-forming subjects will be enrolled in this arm.
Other: Control cohort
12 non-stone-forming subjects will be enrolled in this arm.
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Leads: University of Chicago