Klippel-Trenaunay SyndromeSymptoms, Doctors, Treatments, Advances & More
Learn About Klippel-Trenaunay Syndrome
Klippel-Trenaunay syndrome (KTS) is a rare condition that is typically present at birth. The syndrome often involves port wine stains, excess growth of bones and soft tissue, and varicose veins.
Klippel-Trenaunay-Weber syndrome; KTS; Angio-osteohypertrophy; Hemangiectasia hypertrophicans; Nevus verucosus hypertrophicans; Capillary-lymphatico-venous malformation (CLVM)
KTS is caused by a genetic variation that occurs during fetal development. Why this occurs is unknown.
Symptoms of KTS include:
- Many port wine stains or other blood vessel problems, including dark spots on the skin
- Varicose veins (may be seen in early infancy, but are more likely to be seen later in childhood or adolescence)
- Unstable gait due to limb-length difference (involved limb is longer)
- Bone, vein, or nerve pain
Other possible symptoms:
- Bleeding from the rectum
- Blood in the urine
More information and support for people with KTS and their families can be found at:
- K-T Support Group -- k-t.org
- Vascular Birthmarks Foundation -- birthmark.org
Most people with KTS do well, although the condition may affect their appearance.
Mayo Clinic
Megha Tollefson is a Dermatologist and a Pediatrics provider practicing medicine in Rochester, Minnesota. Dr. Tollefson is rated as an Elite provider by MediFind in the treatment of Klippel-Trenaunay Syndrome. She is also highly rated in 22 other conditions, according to our data. Her clinical expertise encompasses Klippel-Trenaunay Syndrome, Progressive Hemifacial Atrophy, Vascular Birthmark, and Hemangioma. Dr. Tollefson is currently accepting new patients.
St. Christopher's Pediatric Associates Radiology - E. Erie Avenue
. Dr. Contrucci is rated as an Experienced provider by MediFind in the treatment of Klippel-Trenaunay Syndrome. She is also highly rated in 11 other conditions, according to our data. Her clinical expertise encompasses Tracheobronchopathia Osteoplastica, Scoliosis, Short Stature (Growth Disorders), and Idiopathic Short Stature (ISS). Dr. Contrucci is board certified in American Board Of Radiology.
ETSU Physicians & Associates- Pediatrics
. Dr. Anand is rated as an Experienced provider by MediFind in the treatment of Klippel-Trenaunay Syndrome. She is also highly rated in 18 other conditions, according to our data. Her clinical expertise encompasses Pulmonary Supravalvular Stenosis, Pulmonary Valve Stenosis, Patent Ductus Arteriosus, and Familial Dilated Cardiomyopathy. Dr. Anand is board certified in American Board Of Pediatrics.
Summary: This is a 3-part Phase 2 randomized study evaluating the safety and efficacy of the mutant-selective PI3Kα inhibitor, RLY-2608, in adults and children with PIK3CA Related Overgrowth Spectrum (PROS) and malformations driven by PIK3CA mutation. Part 1 is a dose selection, Part 2 is a basket design with exploratory single-arm cohorts for various subpopulations of participants, and Part 3 is randomize...
Summary: Lymphatic anomalies are a rare subset of vascular anomalies that are poorly understood. the understanding of the natural history, long-term outcomes, risk factors for morbidity and mortality, and the relative benefit of medical therapies and procedures is limited.The goal of this project is to better understand these diseases and improve the care of theses rare patients. To do this, the investigat...
Published Date: October 27, 2025
Published By: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Greene AK, Mulliken JB. Vascular anomalies. In: Losee JE, Hopper RA, eds. Plastic Surgery: Volume 3: Craniofacial, Head and Neck Surgery and Pediatric Plastic Surgery. 5th ed. Philadelphia, PA: Elsevier; 2024:chap 31.
K-T Support Group website. Clinical practice guidelines for Klippel-Trenaunay syndrome (KTS). k-t.org/assets/images/content/BCH-Klippel-Trenaunay-Syndrome-Management-Guidelines-1-6-2016.pdf. Updated January 6, 2016. Accessed December 18, 2025.
McCormick AA, Grunwaldt LJ. Vascular anomalies. In: Zitelli BJ, McIntire SC, Nowalk AJ, Garrison J, eds. Zitelli and Davis' Atlas of Pediatric Physical Diagnosis. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 10.
Rausch AC, Longman RE. Klippel-Trenaunay-Weber syndrome. In: Copel JA, D'Alton ME, Feltovich H, et al, eds. Obstetric Imaging: Fetal Diagnosis and Care. 3rd ed. Philadelphia, PA: Elsevier; 2026:chap 138.