Learn About Lactic Acidosis

What is the definition of Lactic Acidosis?

Lactic acidosis refers to lactic acid build up in the bloodstream. Lactic acid is produced when oxygen levels become low in cells within the areas of the body where metabolism takes place.

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What are the causes of Lactic Acidosis?

The most common cause of lactic acidosis is severe medical illness in which blood pressure is low and too little oxygen is reaching the body's tissues. Intense exercise or convulsions can cause temporary lactic acidosis. Certain diseases can also cause the condition, including:

  • AIDS
  • Alcoholism
  • Cancer
  • Cirrhosis
  • Cyanide poisoning
  • Kidney failure
  • Respiratory failure
  • Sepsis (severe infection)

Some medicines can rarely cause lactic acidosis:

  • Beta adrenergic agonist inhalers used to treat asthma or COPD (albuterol and salmeterol)
  • Epinephrine
  • Linezolid
  • Metformin, used to treat diabetes (most often when overdosed)
  • Nucleoside reverse transcriptase inhibitors used to treat HIV infection
  • Propofol
What are the symptoms of Lactic Acidosis?

Symptoms may include:

  • Nausea
  • Vomiting
  • Weakness
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What are the current treatments for Lactic Acidosis?

The main treatment for lactic acidosis is to correct the medical problem that causes the condition.

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What are the latest Lactic Acidosis Clinical Trials?
Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study

Summary: The objective of the METINFO study is an observational single-center retrospective and descriptive study. The main objective is to estimate the real mortality rate associated to a Metformin overdose. Second objectives are to estimate the real hospitalization rate related to metformin overdose and to identify the risk factors of a metformin overdose and especially the potential correlation between ...

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A Phase IIb Open-label, Multi-centre, Extension Study to Explore the Long-term Safety and Efficacy of KH176 in Subjects With a Genetically Confirmed Mitochondrial DNA tRNALeu(UUR) m.3243A>G Mutation Who Have Completed the KHENERGYZE Study KH176-202.

Summary: This is an open-label, multi-centre study in subjects with a genetically confirmed mitochondrial deoxyribonucleic acid (DNA) transfer ribonucleic acid (tRNA)Leu(UUR) m.3243A>G mutation who completed study KH176-202. In the KH176-203 study subjects will be receiving KH176 100 mg BID or KH176 50 mg bid in die (BID) (as determined by the investigator based on safety / tolerability considerations) for...

What are the Latest Advances for Lactic Acidosis?
A Case of Infantile Mitochondrial Cardiomyopathy Treated with a Combination of Low-Dose Propranolol and Cibenzoline for Left Ventricular Outflow Tract Stenosis.
A patient with severe metformin-associated lactic acidosis complicated by acute coronary syndrome: a case report.
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Severe lactic acidosis and persistent diastolic hypotension following standard dose of intermittent nebulized salbutamol in a child: a case report.
Who are the sources who wrote this article ?

Published Date: October 11, 2020
Published By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Palmer BF. Metabolic acidosis. In: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Comprehensive Clinical Nephrology. 6th ed. Philadelphia, PA: Elsevier; 2019:chap 12.

Seifter JL. Acid-base disorders.In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 110.

Strayer RJ. Acid-base disorders. In: Walls RM, Hockberger RS, Gausche-Hill M, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 116.